Description
An agonist of TRβ (EC50s = 0.21 and 3.74 µM for TRβ and TRα, respectively); inhibits hERG channels (IC50 = 30 µM); liver-directed, with a liver to plasma ratio of 8:1 to reduce systemic exposure; does not affect the expression of α-MHC in a rat model of hypothyroidism, an effect mediated by TRα; lowers non-HDL cholesterol and liver triglycerides without affecting Tsh levels in rat and rabbit models of hypercholesterolemia; lowers plasma glucose levels and improves insulin sensitivity in DIO mice