Description
A synthetic glucocorticoid; increases expression of the calcitonin receptor in vitro; has antinociceptive activity in mice; reduces GAGs in keloid implants in mice; has been used in the formation of LNPs for the delivery of mRNA in vitro and in vivo; LNPs containing triamcinolone and encapsulating reporter mRNA reduce LNP-induced increases in the serum levels of inflammatory cytokines in mice to a greater extent than LNPs without triamcinolone; triamcinolone-containing LNPs encapsulating MOG35-55 mRNA reduce spinal cord CD3+ T cell infiltration and disease severity in a mouse model of EAE