Description
An Aurora A kinase inhibitor (IC50 = 1 nM); selective for Aurora A over Aurora B kinase (IC50 = 396.5 nM); induces cell cycle arrest at the G2/M phase and chromosomal misalignment in HCT116 cells at 50 nM; inhibits tumor growth in a Calu-6 NSCLC mouse xenograft model at 20 mg/kg