Description
A noradrenergic neurotoxin; inhibits the uptake of norepinephrine in rat cortical homogenates; reduces dopamine-β-hydroxylase activity in rat brain and selectively depletes norepinephrine in rat cortex and locus coeruleus over the ventral forebrain, hypothalamus, and periphery; impairs tactile learning in the novel object recognition task in rats at 50 mg/kg; decreases exploration in a novel open area and neophilia in a complex exploration test in rats