Description
An inhibitor of Cdk12 and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively); selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 µM, respectively); inhibits proliferation of Jurkat cells (IC50 = 50 nM); induces apoptosis in Jurkat cells in a concentration-dependent manner; reduces expression of genes associated with the DNA damage response, including BRCA1, FANCF, and ERCC4, in Jurkat cells at 50 nM