Description
An allosteric agonist of M1 mAChRs (EC50 = 158 nM in CHO-K1 cells expressing rat recombinant receptors); selective for M1 over M2-5 receptors at concentrations up to 10 µM; potentiates NMDA-evoked currents in CA1 pyramidal cells at 3 µM; increases production of the non-amyloidogenic APP cleavage products APPsα and CTFα in PC12 cells overexpressing the human M1 receptor and APP at 1 µM; decreases amphetamine-induced hyperlocomotion in in a rat model that is predictive of antipsychotic-like activity