Description
An FLT3 kinase inhibitor (IC50s = 2.1-38.1 nM for wild-type and constitutively active mutant FLT3s); inhibits growth of human leukemia cell lines that express FLT3-ITD mutant kinase (IC50s = 3.5 and 7.5 nM for MV4-11 and Molm-14 cells, respectively); reduces tumor growth and increases survival in a dose-dependent manner in MV4-11 and Molm-14 murine leukemia xenograft models; reduces growth of bone marrow blasts derived from acute myeloid leukemia patients