680C91 from Tocris Bioscience, a Bio-Techne Brand | Biocompare.com

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680C91

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

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Tocris Bioscience, a Bio-Techne Brand for
680C91

Description

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

Product Specs
Item680C91
CompanyTocris Bioscience, a Bio-Techne Brand
Price $124.00Supplier Page View Company Product Page
Catalog Number4392/5
Quantity5 mg (also 25 mg)
Purity98%
Molecular Weight238.26
Molecule Name6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole
FormulaC15H11FN2
StorageStore at +4°C

Specifications/Features

Sizes Available: 5 mg (also 25 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cellsNAR cancerJune 1, 2021Reed MR, Maddukuri L, Ketkar A, Byrum SD, Zafar MK, Bostian ACL, Tackett AJ, Eoff RL.

(2) Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39Nature neuroscienceMay 1, 2019Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, et al.

(3) Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolitesProceedings of the National Academy of Sciences of the United States of AmericaMay 10, 2016Breda C, Sathyasaikumar KV, Sograte Idrissi S, Notarangelo FM, Estranero JG, Moore GG, Green EW, Kyriacou CP, Schwarcz R, Giorgini F.

(4) Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma CellsChemical research in toxicologyJanuary 19, 2016Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis L, Pouncey DL, Miller GP, Eoff RL.

(5) A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancerCancer researchNovember 1, 2015D'Amato NC, Rogers TJ, Gordon MA, Greene LI, Cochrane DR, Spoelstra NS, Nemkov TG, D'Alessandro A, Hansen KC, Richer JK.

(6) Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myelomaJournal of translational medicineDecember 11, 2012Bonanno G, Mariotti A, Procoli A, Folgiero V, Natale D, De Rosa L, Majolino I, Novarese L, Rocci A, Gambella M, et al.

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