Description
Mast cells are granulocytes found in tissues and are key mediators of allergic inflammation. They are characterized by their expression of receptors for immunoglobulin E (IgE). When these receptors are engaged by IgE bound to antigen, the mast cell releases a number of substances including the notorious histamine. Mast cells are the cells that make allergic individuals miserable, or in the case of some food allergies, the release of histamine and other mediators contribute to a fatal allergic reaction. The Mouse Mast Cells from Creative Bioarray are bone marrow derived mast cells. Expression of CD117 and FCepsilonR1 increase upon culture in the presence of IL-3 and stem cell factor (SCF)