Description
The Immortalized Rat Sympathoadrenal Progenitor Cells (MAH-A3) are derived from HNK-1+ cell population isolated from embryonic rats and that are immortalized using the v-myc oncogene. The cells exhibit morphology resembling the primary cells, and expresses progenitor-specific markers (HNK-1, TH, SCG10, and NF68) and surface antigens such as L1, N-CAM, and Thy-1. MAH-A3 cells are undifferentiated precursors that do not express NGF receptors; however but when cultured in the presence of basic fibroblast growth factor (bFGF), the cells become NGFR-positive post-mitotic sympathetic neurons. MAH-A3 cells are research tools recommended to study the sympathetic development mechanisms