Description
Activated primary rat portal fibroblasts (PF) sorted via the Ntpdase2/Cd39l1 marker were immortalized with the SV40 large T antigen to generate Immortalized Rat Portal Myofibroblasts (RGF-N2). RGF-N2 cells, like primary PFs, demonstrate inhibition of cholangiocyte proliferation in co-culture conditions. The easily transfectable nature of these cells make them an ideal research tool for studying both the function of myofibroblasts and their contribution to liver fibrosis progression