Description
Immortalized Mouse Distal Tubule KDT3 Cells are spontaneously immortal derived cells from murine kidney. KDT3 cells expresses the Ca2+-permeable non-selective cation channel, TRPV4, mostly in the basolateral membrane compared to the apical membrane. Studies have shown some association with extracellular Ca2+levels and the uptake of aminoglycoside. This cell line may be used to study the effects and mechanism of aminoglycoside antibiotics permeation through TRPV4