Description
Introduction: Introduction: Neuropilin-1 (NRP-1) interacts with Vascular endothelial growth factor (VEGF)*1. NRP-1 expression has been shown to beelevated in human patient tumor samples including brain, prostate, breast, colon, and lung cancers*2. As a co-receptor forVEGF, NRP-1 is a potential target for cancer therapies. It has been shown that NRP-1 may facilitate entry the SARS-CoV2 virus into cells by promoting the interaction of the virus with Angiotensin-converting Enzyme 2 (ACE2)*3, so it is also apossible target for future antiviral drugs.
Description: This HEK293-hNRP1-hACE2 stable cell line expresses a recombinant human Neuropilin-1 (NRP-1) and a human Angiotensin-Converting Enzyme 2 (ACE2). The expression of NRP1 has been confirmed by RT-PCR. It can be used for drug screening and for studying SARS-CoV-2 viral entry