Description
Introduction: ACE2 is known to serve as the entry point into cells for some coronaviruses, including HCoV-NL63, SARS-CoV, and SARS-CoV-2. Cells in the lungs, arteries, heart, kidney, and intestines, express high level of ACE2 on their membrane surface. ACE2 is a promising drug target for treating cardiovascular diseases and for preventing COVID-19.
Description: This HEK293-hACE2 stable cell line expresses a recombinant human ACE2 (Angiotensin-Converting Enzyme 2) with the Green Fluorescent Protein (GFP) fused to its C-terminus. The cells have GFP signals on the cell membrane. The expression of ACE2 on the cell membrane was also confirmed with FACS analysis.
Gene/Enzyme Introduced: 1) Human ACE2 (EC 3.4.17.23) Other name(s): ACE-2; ACE2; hACE2; angiotensin converting enzyme 2; angiotensin converting enzyme-2; Tmem27
2) GFP (Green Fluorescent Protein)