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Cloning and Expression
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KRAS mutant-A375 Isogenic Cell Line
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KRAS mutant-A375 Isogenic Cell Line
KRAS mutant-A375 Isogenic Cell Line
KRAS mutant-A375 Isogenic Cell Line from ATCC
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(1)
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KRAS mutant-A375 Isogenic Cell Line
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Product Specs
Item
KRAS mutant-A375 Isogenic Cell Line
Company
ATCC
Price
$4,586.00
Supplier Page
View Company Product Page
Catalog Number
CRL-1619IG-1
Cell Line
A-375
Applications
Anti-cancer drug screening, BRAF drug resistant melanoma model, tumor-associated KRASG13D/BRAFV600E research, RAS-RAF kinase signaling pathway. Ideally the parental cell line (ATCC® CRL-1619™) is included as a control for drug-sensitive response in experiments with this cell line
Tissue
Skin
Type
Cell Biology
Species
Homo sapiens
Quantity
>= 1.0 x 10^6
Age
54 years
Disease
Malignant Melanoma
Volume
1.0 mL
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ATCC
10801 University Boulevard
Manassas
,
Virginia
20110-2209
United States
Phone
: (703) 365-2700
Fax: (703) 365-2701
Company Profile
Website:
http://www.atcc.org
Citations (1)
(1)
CRISPR/Cas9 Edited RAS & MEK Mutant Cells Acquire BRAF and MEK Inhibitor Resistance with MEK1 Q56P Restoring Sensitivity to MEK/BRAF Inhibitor Combo and KRAS G13D Gaining Sensitivity to Immunotherapy
Cancers
November 5, 2022
Turner E, Chen L, Foulke JG, Gu Z, Tian F.
Cloning
The
melanoma
cell line A375 (
ATCC
,
CRL-1619
) and the derived isogenic lines A375 KRAS G13D (
ATCC
,
CRL-1619IG-1
), A375 NRAS Q61K (
ATCC
,
CRL-1619IG-2
) and A375
MEK1
Q56P (
ATCC
,
CRL-1619IG-3
) were grown and maintained
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KRAS mutant-A375 Isogenic Cell Line from ATCC
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$4,586.00
Product Specs
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