TMPRSS2 - Vero E6 Recombinant Cell Line from BPS Bioscience, Inc.

Product Specs
ItemTMPRSS2 - Vero E6 Recombinant Cell Line
CompanyBPS Bioscience, Inc.
Price $12,235.00Supplier Page View Company Product Page
Catalog Number78081
TypeCell Line
Quantity2 vials
ApplicationsThis cell line is useful for screening human TMPRSS2 inhibitors
Source/Expression SystemAfrican green monkey
VeroE6

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BPS Bioscience, Inc.

6405 Mira Mesa Blvd

Suite 100

San Diego, CA 92121

United States

Phone: 858-202-1401

Email: sales-team@bpsbioscience.com

Company Profile

Website: https://bpsbioscience.com/

(1) The buried S2 apex of SARS-CoV-2 spike elicits an immunodominant germline-restricted public antibody responsebioRxivFebruary 21, 2026Suncheol Park, Jacob Mischka, Nisreen Okba, Anass Abbad, Meng Yuan, Komal Srivastava, Charles Gleason, Lubbertus C.F. Mulder, Jeffrey Copps, Katrina Saam, et al.Cell culture Vero.E6 cells expressing transmembrane protease serine 2 (TMPRSS2) (BPS Biosciences, cat. no. 78081) were maintained in Dulbecco’s modified Eagle’s medium (DMEM; Gibco, cat. no. 11965092) supplemented

(2) A conserved long-range RNA interaction in SARS-CoV-2 recruits ADAR1 to enhance virus proliferationNature CommunicationsSeptember 26, 2025Siwy Ling Yang, Louis DeFalco, Sainan Wang, Yi Hao Wong, Jian Han, Chee Keng Mok, Kiat Yee Tan, Su Ying Lim, Zhiya Zhao, Yu Zhang, et al.CRL-1586) and Vero-E6 cells constitutively expressing human TMPRSS2 (Vero-E6/TMPRSS2; BPS Bioscience #78081) were used in this study. Vero-E6 cells were cultured in Dulbecco’s Modified Eagle Medium (DMEM; Cytiva,

(3) SARS-CoV-2 causes chronic lung inflammation and impaired respiratory capacity in aged Roborovski dwarf hamstersJournal of VirologySeptember 23, 2025Amirhossein Karimi, Carolin M. Lieber, Kaori Sakamoto, Richard K. Plemperfor 7–14 dpi. Cells and viruses African green monkey kidney cells VeroE6-TMPRSS2 (BPS Bioscience #78081) were cultured at 37°C with 5% CO2 in Dulbecco’s Modified Eagle’s Medium (DMEM) with 7.5% heat-inactivated

(4) Antibody responses to SARS-CoV-2 variants LP.8.1, LF.7.1, NB.1.8.1, XFG and BA.3.2 following KP.2 monovalent mRNA vaccinationmedRxivSeptember 23, 2025Anass Abbad, Brian Lerman, Jordan Ehrenhaus, Brian Monahan, Gagandeep Singh, Adria Wilson, Stefan Slamanig, Ashley Aracena, Neko Lyttle, Jessica Nardulli, et al.Cell culture Vero-E6 cells expressing transmembrane protease serine 2 (TMPRSS2) (BPS Biosciences, cat. no. 78081) were maintained in Dulbecco's modified Eagle's medium (DMEM; Gibco, cat. no. 11965092) supplemented

(5) Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitopeCell ReportsAugust 26, 2025Vishal N. Rao, Iden A. Sapse, Hallie Cohn, Duck-Kyun Yoo, Pei Tong, Jordan J. Clark, Bailey Bozarth, Yuexing Chen, Komal Srivastava, Gagandeep Singh, et al.S1. Cells and viruses Vero E6 cells expressing transmembrane protease serine 2 (TMPRSS2; BPS Biosciences, 78081) were maintained in Dulbecco’s modified Eagle medium (DMEM; Gibco) supplemented with 10% fetal bovine

(6) Dissecting Sex-Specific Pathology in K18-hACE2 Transgenic Mice Infected With Different SARS-CoV-2 VariantsJ Med VirolJuly 21, 2025Elysia A. Masters, Weichun Tang, Insung Kang, Martina Kosikova, Jennifer H. Hanks, Lana Elkins, Hyung-Joon Kwon, Uriel Ortega-Rodriguez, Binsheng Gong, Kelly E. Mercer, et al.Methods 2.1 Cells and Viruses Vero E6 stably transfected with human TMPRSS2 (TMPRSS2‐E6) (BPS Bioscience #78081) was maintained in Gibco high‐glucose Dulbecco's modified Eagle's medium (DMEM) supplemented with 10%

(7) Mucosal and Serum Neutralization Immune Responses Elicited by COVID-19 mRNA Vaccination in Vaccinated and Breakthrough-Infection Individuals: A Longitudinal Study from Louisville CohortVaccines (Basel)May 24, 2025Lalit Batra, Divyasha Saxena, Triparna Poddar, Maryam Zahin, Alok Amraotkar, Megan M. Bezold, Kathleen T. Kitterman, Kailyn A. Deitz, Amanda B. Lasnik, Rachel J. Keith, et al.Viruses TMPRSS2-overexpressing VeroE6 recombinant cells (BPS Biosciences, San Diego, CA, USA, Catalog #78081) were used for viral infection and propagation, avoiding cell culture adaptation-mutations which may

(8) The impact of S2 mutations on Omicron SARS-CoV-2 cell surface expression and fusogenicityEmerging microbes & infectionsDecember 1, 2024Escalera A, Laporte M, Turner S, Karakus U, Gonzalez-Reiche AS, van de Guchte A, Farrugia K, Khalil Z, van Bakel H, Smith D, et al.constitutively expressing full-length human TMPRSS2 (Vero-TMPRSS2) was purchased from BPS Bioscience (78081). Human HEK293T cells were originally purchased from the American Type Culture Collection (ATCC). Human

(9) Adaptive Multi-Epitope Targeting and Avidity-Enhanced (AMETA) Nanobody Platform: Leveraging Diverse Mechanisms for Ultrapotent, Durable Antiviral TherapyCellNovember 27, 2024Yufei Xiang, Jialu Xu, Briana L. McGovern, Anna Ranzenigo, Wei Huang, Zhe Sang, Juan Shen, Randy Diaz-tapia, Ngoc Dung Pham, Abraham J.P. Teunissen, et al.lines Expi293F cells,Thermo Fisher,A14635 Vero-E6 cell,ATCC,CRL-1586™ Vero-E6-TMPRSS2,BPS Bioscience,78081 HeLa-ACE2,BPS Bioscience,79958 293T-hsACE2,Integral Molecular,C-HA101 Oligonucleotides,Oligonucleotides,Oligonucleotides ST3-F:

(10) Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccinationCell ReportsNovember 26, 2024Jordan J. Clark, Irene Hoxie, Daniel C. Adelsberg, Iden A. Sapse, Robert Andreata-Santos, Jeremy S. Yong, Fatima Amanat, Johnstone Tcheou, Ariel Raskin, Gagandeep Singh, et al.incubator with 5% CO2. Vero.E6 cells expressing transmembrane protease, serine 2 (TMPRSS2, BPS Biosciences, 78081) were cultured in Dulbecco’s modified Eagle medium (DMEM; Gibco) supplemented with 10% FBS, 1% minimal

(11) Outcome of SARS-CoV-2 reinfection depends on genetic background in female miceNature CommunicationsNovember 23, 2024Gagandeep Singh, Juan García-Bernalt Diego, Prajakta Warang, Seok-Chan Park, Lauren A. Chang, Moataz Noureddine, Gabriel Laghlali, Yonina Bykov, Matthew Prellberg, Vivian Yan, et al.SARS-CoV-2 infection in mouse models. Methods Cells and viruses Vero-TMPRSS2 cells (BPS Bioscience, Cat# 78081) were cultured at 37 °C in 1X DMEM (Dulbecco’s modified Eagle medium) supplemented with 10% FBS (fetal

(12) Vaccination with ancestral SARS-CoV-2 spike adjuvanted with TLR agonists provides cross-protection against XBB.1npj VirusesAugust 6, 2024Stephanie K. Lathrop, Jordan J. Clark, Karthik Siram, Robert Andreata-Santos, Jeremy Yong, Rebekah D. Tee, Clara J. Davison, Gagandeep Singh, David Burkhart, Florian Krammer, et al.level 3 (BSL3) laboratory. Vero.E6 cells expressing transmembrane protease, serine 2 (TMPRSS2 cat. 78081, BPS Biosciences, San Diego, CA, USA) were seeded in a 96-well cell culture plate (Corning; 3340) at

(13) Immunogenicity and protective efficacy of the HC009 mRNA vaccine against SARS-CoV-2Frontiers in ImmunologyJuly 26, 2024Juan Liu, Huafeng Han, Binbin Yang, Naifang Zhang, Jing Li, Xicheng Chen, Jie Wu, Yingying Zhao, Yongsheng Yangseparated by the Wuhan Institute of Virology was propagated in Vero E6-TMPRSS2 cells (BPS Bioscience, 78081, USA). All experiments involving SARS-CoV-2 infection were performed under Biosafety Level 3 facilities.

(14) Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccinesbioRxivJuly 19, 2024Raianna F. Fantin, Jordan J. Clark, Hallie Cohn, Deepika Jaiswal, Bailey Bozarth, Alesandro Civljak, Vishal Rao, Igor Lobo, Jessica R. Nardulli, Komal Srivastava, et al.nanometers. Neutralization assays Vero E6 cells expressing transmembrane protease serine 2 (TMPRSS2, BPS Biosciences, 78081) were cultured in Dulbecco’s modified Eagle medium (DMEM; Gibco) supplemented with 10% fetal bovine

(15) Single-shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad, durable and protective systemic and mucosal immunity in miceMolecular TherapyJuly 3, 2024Nicholas You Zhi Cheang, Kai Sen Tan, Peck Szee Tan, Kiren Purushotorma, Wee Chee Yap, Kirsteen McInnes Tullett, Benson Yen Leong Chua, Aileen Ying-Yan Yeoh, Caris Qi Hui Tan, Xinlei Qian, et al.TMPRSS2-overexpressing African green monkey (Chlorocebus aethiops)-derived kidney epithelial (VeroE6/TMPRSS2) cells) (78081; BPS Bioscience, San Diego, CA, USA) were maintained in DMEM (11965-118; GIBCO, Thermo Fisher Scientific)

(16) Nanoscale cellular organization of viral RNA and proteins in SARS-CoV-2 replication organellesNature communicationsMay 31, 2024Andronov L, Han M, Zhu Y, Balaji A, Roy AR, Barentine AES, Patel P, Garhyan J, Qi LS, Moerner WE.(human embryonic kidney epithelial cells, ATCC, CRL-3216), and Vero E6-TMPRSS2 cells (BPS Bioscience, 78081) were cultured in Dulbecco’s modified Eagle medium (DMEM) with GlutaMAX, 25 mM D-Glucose, and 1 mM sodium

(17) SARS-CoV-2 BA.1 and BA.2 breakthrough infections boost antibody responses to early Omicron subvariants but not BQ.1.1 or XBB.1.5Cell Reports MedicineMarch 19, 2024Anass Abbad, Temima Yellin, Gagandeep Singh, Miriam Fried, Ariel Raskin, Johnstone Tcheou, Brian Monahan, Charles Gleason, Dalles Andre, Maria C. Bermúdez-González, et al.Vero-E6 cells expressing transmembrane protease serine 2 (TMPRSS2) (BPS Biosciences, catalog (cat.) no. 78081) were cultured in Dulbecco’s modified Eagles medium (DMEM; Gibco, cat. no. 11965092) containing 10%

(18) Intestinal microbiota programming of alveolar macrophages influences severity of respiratory viral infectionCell Host & MicrobeMarch 13, 2024Vu L. Ngo, Carolin M. Lieber, Hae-ji Kang, Kaori Sakamoto, Michal Kuczma, Richard K. Plemper, Andrew T. GewirtzMadin-Darby Canine Kidney (MDCK; ATCC CCL-34), HEp-2 (ATCC CCL-23), and VeroE6 TMPRSS2 (BPS Bioscience #78081) cells were cultured in Dulbecco’s Modified Eagle’s Medium (DMEM) supplemented with 7.5% heat-inactivated

(19) Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formationNature CommunicationsSeptember 18, 2023Qi Zhang, Weichun Tang, Eduardo Stancanelli, Eunkyung Jung, Zulfeqhar Syed, Vijayakanth Pagadala, Layla Saidi, Catherine Z. Chen, Peng Gao, Miao Xu, et al.Agreement. Calu-3 cells (HTB-55) and Vero E6 cells (CRL-1586) were purchased from ATCC. Vero TMPRSS2-E6 (TE6) (78081), a Vero E6-based cell line stably transfected with human TMPRSS2 was obtained from BPS Bioscience (San

(20) Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal modelsNat CommunAugust 7, 2023Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Amirhossein Karimi, Nicole A. P. Lieberman, Zachary M. Sticher, Pavitra Roychoudhury, Meghan K. Andrews, Rebecca E. Krueger, Michael G. Natchus, et al.determined by plaque assays or TCID50 and RT-qPCR quantitation. Cells VeroE6-TMPRSS2 (BPS Bioscience #78081) and Calu-3 (ATCC HB-55TM) cells were cultivated at 37 °C with 5% CO2 in Dulbecco’s modified Eagle’s medium (DMEM

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