Description
Human Adenovirus Type5 (dE1/E3) expressing mouse c-Rel under a CMV promoter with co-expression of GFP.The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma. This pre-packaged c-Rel adenovirus (Ad-cRel) expresses c-Rel from mouse with co-expression of GFP