PathHunter® U2OS Keap1-NRF2 Nuclear Translocation Cell Line from DiscoverX

Product Specs
ItemPathHunter® U2OS Keap1-NRF2 Nuclear Translocation Cell Line
CompanyDiscoverX
Price $20,595.00Supplier Page View Company Product Page
Catalog Number93-0821C3
QuantityClone
ApplicationsPathway Nuclear Translocation Assays
ReactivityHuman
TypeCell Line
TargetKeap1-NRF2
Research AreaPathway Nuclear Translocation Assays

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DiscoveRx Corporation 42501 Albrae St.

Fremont, California 94538

United States

Phone: (510) 979-1415

Email: CustomerServiceDRX@eurofins.com

Company Profile

Website: http://www.discoverx.com

(1) Design, Synthesis, and Biological Evaluation of Novel Vinyl Selenone Derivatives as Potent Nrf2 Activators for Atopic DermatitisJournal of Medicinal ChemistryApril 9, 2026Jushin Kim, Yoowon Kim, Byungeun Kim, Elijah Hwejin Lee, Rium Kim, Jiwoo Park, Jaehwan Kim, Yonghan Kim, Sang In Park, Minsik Kang, et al.investigate Keap1-Nrf2 nuclear translocation, the PathHunter U2OS Keap1-Nrf2 nuclear translocation cell line (93-0821C3, DiscoverX, Fremont, CA, USA) was cultured in AssayComplete cell culture medium (92-3103G, DiscoverX)

(2) Covalent Inhibitors of KEAP1 with Exquisite SelectivityJournal of Medicinal ChemistryDecember 12, 2024Imre Fejes, Piroska Markacz, Janos Tatai, Monika Rudas, Petra Dunkel, Mario Gyuris, Miklos Nyerges, Nicolas Provost, Valérie Duvivier, Philippe Delerive, et al.and acceptor enzyme in the nucleus (PathHunter U2OS Keap1-NRF2 Nuclear Translocation Cell Line, ref.93–0821C3, DiscoverX). PathHunter U2OS cells were grown in minimum essential medium (MEM) (ref.30–2003, ATCC),

(3) Discovery and Optimization of a Series of Vinyl Sulfoximine-Based Analogues as Potent Nrf2 Activators for the Treatment of Multiple SclerosisJournal of medicinal chemistryOctober 10, 2024Kim Y, Kim J, Kim B, Kim R, Kim HJ, Lee EH, Kim J, Park J, Jeong Y, Park SI, et al.°C in a 5% CO2 humidified incubator. The PathHunter U2OS Keap1-NRF2 nuclear translocation cell line (93-0821C3, DiscoverX, Fremont, CA, USA) used for the Keap1-Nrf2 nuclear translocation assay was cultured in AssayComplete Cell culture kit-103

(4) Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 ActivatorACS Medicinal Chemistry LettersJuly 11, 2019Ji Won Choi, Su Jeong Shin, Hyeon Ji Kim, Jong-Hyun Park, Hyeon Jeong Kim, Elijah Hwejin Lee, Ae Nim Pae, Yong Sun Bahn, Ki Duk Park0.039 ± ± ± ± ± ± ± ± ± ± ± ± ± 0.015 0.047 0.009 0.026 0.015 0.016 0.050 0.028 0.024 0.030 0.036 0.025 0.024 a The Nrf2 functional assay was accomplished by a PathHunter U2OS Nrf2 nuclear translocation cell line (93-0821C3, DiscoveRx). U2OS cells were plated at 13,000 cells/well in triplicate with various compound concentrations

(5) Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interactionBioorganic & medicinal chemistry lettersMay 15, 2013Hu L, Magesh S, Chen L, Wang L, Lewis TA, Chen Y, Khodier C, Inoyama D, Beamer LJ, Emge TJ, et al.Invitrogen. CellSensor™ ARE-bla Hep G2 Cell-based Assay Protocol. 2006. p. 8 25. DiscoveRx. Product Booklet: 93-0821C3. 2011. PathHunter® Keap1-Nrf2 Functional Assay for chemiluminescent detection of activated Nrf2; p.

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PathHunter® U2OS Keap1-NRF2 Nuclear Translocation Cell Line from DiscoverX

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PathHunter® U2OS Keap1-NRF2 Nuclear Translocation Cell Line from DiscoverX

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