Description
S100 calcium-binding protein A12 (S100A12) is also known as Extracellular newly identified RAGE-binding protein (EN-RAGE), Calgranulin-C (CAGC), Calcium-binding protein in amniotic fluid 1 (CAAF1), Migration inhibitory factor-related protein 6 (MRP-6), Neutrophil S100 protein, which contains two EF-hand domains and belongs to the S-101 family. S100A12 is homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. S100A12 interacts with AGER and both calcium and zinc are essential for the interaction and also interacts with CACYBP in a calcium-dependent manner. S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response