Description
Product Characteristics: Purified native Human MPO protein
Bioactivity: 180-220 units/mg after lyophilization - One unit of activity is defined as the amount of enzyme that will decompose one micromole of hydrogen peroxide per minute at 25o C, pH 6.1. Reaction mixture contains 33 mM sodium phosphate, pH 6.1, 30 mM guaiacol, and 0.0012 % (0.35 mM) hydrogen peroxide.
Protein Source: Human neutrophils
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Target Information: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]