Description
Description: PPP1R8 Human Recombinant produced in E Coli is a single polypeptide chain containing 359 amino acids (1-351) and having a molecular mass of 39.5 kDa.PPP1R8 is fused to a 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Introduction: Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) is the RNA-binding subunit of a key species of protein phosphatase-1 in the nucleus. The PPP1R8 enzyme is an inhibitor subunit of the main nuclear protein phosphatase-1 (PP-1). PPP1R8 has RNA-binding activity however it doesn't cleave RNA and may target PP-1 to RNA-associated substrates. Two isoforms of the PPP1R8 protein are specific inhibitors of type 1 serine/threonine protein phosphatases which can bind but not cleave RNA. The third isoform of the PPP1R8 protein is deficient in of the phosphatase inhibitory activity nonetheless it is a single-strand endoribonuclease comparable to RNase E of E. coli