Description
MAPK3 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Activation of MAPK3 requires both tyrosine and threonine phosphorylation that is mediated by MEK. MAPK3 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated MAPK3 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta)