Description
Il28ra isa type I transmembrane glycoprotein that is cytokine receptor family 2 member12 (CRF2-12). It pairs with the IL-10 receptor β subunit (IL-10 Rβ, CRF2-4)to form the IL-28 R. Each subunit of this receptor can interact with theinterferon-like cytokines (type III interferons) IL-28A (IFN-λ2), IL-28B(IFN-λ3) and IL-29 (IFN-λ1). Mouse IL 28A and IL-28B share 97% amino acid(aa) identity rodents do not express IL-29. Mouse Il28ra cDNA encodes a 535 aaprotein with a 20 aa signal peptide, a 207 aa extracellular domain (ECD) witha fibronectin type III motif and four potential N-glycosylation sites, a 21 aatransmembrane sequence, and a proline-rich and acidic 287 aa cytoplasmicdomain