Description
Mapk8 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. Mapk8 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. Mapk8 has been shown to play an important role in disease processes. Activation of Mapk8 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction. Mapk8 activity is also abnormally elevated in obesity and removal of Mapk8 results in decreased adiposity and significantly improved insulin sensitivity