Fig 1: The Areg mediates the interaction between γδT cells and keratinocytes.A The information stream plot indicating the incoming and outgoing interaction strength in T cells and keratinocytes. The most intense outgoing interaction of T cells to keratinocytes in TLR9agonist_LW was launched by γδT cells, but in WT_LW it was Th2. B The differential interaction pathways in TLR9agonist_LW and WT_LW. C The interaction numbers between T cells and keratinocytes in TLR9agonist_LW and WT_LW. D The bubble diagram showing the pathways mediating the interaction between γδT cells and keratinocytes in two groups. E The expression level of Areg in γδT cells. F Immunofluorescence staining was performed to visualize the expression of the AREG protein in skin wounds with different treatments at PWD7, PWD10, SD2, respectively. G The mRNA changes of areg in WT_LW, TCRdelta−/−_LW and TLR9agonist+ TCRdelta−/−_LW at SD2. H The number of hair follicles at PWD28 in different group. I The healing speed differences in different group. The injection of anti-AREG (15 μg per time per mouse. HY-P77868, MedChemExpress) or Control-IgG (30000-0-AP, Proteintech) into the wound bed was conducted at PWD 0,3,6,10. J The mRNA changes of Areg, Wnt10b, Ctnnb1, Twist1, Twist2 in Hacat cells after culturing with various concentrations of rhAREG for 48 h.