Description
Secretory Immunoglobulin A (SIgA) is the primary immunoglobulin on most mucosal surfaces made of two IgA monomers, a connecting J chain, and the secretory component (SC). The SC protects the secretory IgA complex from proteases present in the mucosal environment. Secretory IgA serves several functions, including neutralization of viruses and exotoxin, enhancement of lactoferrin and lactoperoxidase activities, and inhibition of microbial growth. Because dimeric IgA is able to bind two antigens simultaneously, it is capable of forming large antigen-antibody complexes that neutralizes microbes and facilitates their removal