Description
A peptide inhibitor of the MD-2-CIRP protein-protein interaction; binds to MD-2 and disrupts the interaction between MD-2 and CIRP in co-immunoprecipitation assays; reduces infarct volume in a mouse model of MCAO-induced stroke at 10 and 20 mg/kg; reduces infarct volume and decreases the time to pick up and withdraw food with the stroke-affected arm in a rhesus monkey model of thrombosis-induced stroke