Description
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II. In addition to its role in inhibiting inflammatory immune responses, also plays a role in hepatocytes. Under normal physiological conditions, primarily secreted from hepatocytes and contributes to its mitogenic and metabolic functions