Description
Human Interferon-alpha 2a is an interferon class I produced by the cells of the innate immune system as a part of the defense response to foreign agents such as viruses, parasites and tumor cells. The human alpha-interferon family displays broad spectrum antiviral, antiproliferative and immunomodulatory activities on a variety of cell types. Interferon-alpha 2a (IFNa-2a), one of the subtypes, is a protein consisting of 165 amino acids. Its three-dimensional loop structure is maintained by two disulfide bridges. It has an approximate molecular weight of 20 kDa. Recombinant human IFN-alpha 2a is a polypeptide single chain containing 171 amino acids with a predicted molecular mass of 20.1 kDa. It contains a His-tag at the C-terminal end. Human recombinant IFN-alpha 2a expressed in Nicotiana benthamiana is produced by transient expression in non-transgenic plants and is purified by sequential chromatography (FPLC). This product does not contain any animal–derived components or impurities