TRADD Recombinant Protein (Human) (OPCA04716) from Aviva Systems Biology

Description

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B

Product Specs
ItemTRADD Recombinant Protein (Human) (OPCA04716)
CompanyAviva Systems Biology
Price Supplier Page View Company Product Page
Catalog NumberOPCA04716
Size25ul, 100ul
TypeProtein
Molecule NameTumor necrosis factor receptor type 1-associated DEATH domain protein
SpeciesHomo sapiens, Human
FormatIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0., Liquid or Lyophilized powder
PurityGreater than 90% as determined by SDS-PAGE
Gene NameTNFRSF1A associated via death domain
Molecular Weight61.2 kDa
NCBI Gene AliasesHs.89862
Conjugate/TagN-terminal GST-tagged
Source/Expression SystemE.coli

Sequence

MAAGQNGHEE WVGSAYLFVE SSLDKVVLSD AYAHPQQKVA VYRALQAALA ESGGSPDVLQ MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ RSLAAALAQH SVPLQLELRA GAERLDALLA DEERCLSCIL AQQPDRLRDE ELAELEDALR NLKCGSGARG GDGEVASAPL QPPVPSLSEV KPPPPPPPAQ TFLFQGQPVV NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG CRALRDPALD SLAYEYEREG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED LLGLTDPNGG LA

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