Alpha Synuclein Oligomers SPR-484 from StressMarq Biosciences Inc

Product Specs
ItemAlpha Synuclein Oligomers
CompanyStressMarq Biosciences Inc
Price Supplier Page View Company Product Page
Catalog NumberSPR-484
ApplicationsWB, Native PAGE, In vivo assay, In vitro assay
Size100 µg
Research AreaNeuroscience, Neurodegeneration, Alzheimer's Disease, Tangles & Tau, Neuroscience, Neurodegeneration, Parkinson's Disease, Synuclein, Neuroscience, Neurodegeneration, Multiple System Atrophy
NCBI Full Gene Namesynuclein alpha
NCBI Gene AliasesPARK4, NACP, PARK1, PD1
Conjugate/TagNo Tag
TypeProtein
Source/Expression SystemE. coli
Purity>95%
SpeciesHuman

Sequence

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

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StressMarq Biosciences Inc

117-1537 Hillside Ave.

Victoria, British Columbia V8T 4Y2

Canada

Phone: +1-250-294-9065
Fax: 1-250-294-9025

Email: info@stressmarq.com

Company Profile

Website: http://www.stressmarq.com

(1) Perivascular spread of CSF-derived α-synuclein oligomers drives region-specific Parkinson’s-like pathologynpj Parkinson's DiseaseFebruary 25, 2026Wen-Xin Zhu, Xu-Zhong He, Jing-Cai Meng, Yi-Xuan Dong, Jing-Ru Hou, Rong Xue, Guo-Xing Zhang, Lin-Hui Wangphenotypes and treatments. ICV injection According to a previous study10, α-syn oligomers (α-SOs, SPR484, StressMarq Biosciences, Victoria, Canada) were diluted in PBS (1 mg/mL or 0.33 mg/mL) and stereotaxically

(2) Differential microglial responses to structurally distinct alpha-synuclein polymorphsMolecular BrainDecember 5, 2025Katherine Chang, Jina Kim, Michiyo Iba, Jae-Hyeon Park, Alexandria Beilina, Zulfeqhar A. Syed, Valentina Baena, Liam Horan-Portelance, Mark R. Cookson, Sungyong You, et al.aggregates Recombinant human α-synuclein monomers (#SPR-316, MO), kinetically stable α-synuclein oligomers (#SPR-484, KSO), EGCG stabilized α-synuclein oligomers (#SPR-469, EO), dopamine stabilized α-synuclein oligomers

(3) The Neurotoxic Properties of α-synuclein PolymorphsExperimental neurobiologyJune 30, 2025Chang K, Syed Z, Baena V, Cookson MR, Kim C.monomers (#SPR-316, MO), α-syn preformed fibrils (#SPR-322, PFF), kinetically stable α-syn oligomers (#SPR-484, KSO), dopamine stabilized α-syn oligomers (#SPR-466, DO), and epigallocatechin gallate (EGCG) stabilized

(4) Facile generation of drug-like conformational antibodies specific for amyloid fibrilsNature chemical biologyJune 1, 2025Desai AA, Zupancic JM, Trzeciakiewicz H, Gerson JE, DuBois KN, Skinner ME, Sharkey LM, McArthur N, Ferris SP, Bhatt NN, et al.30 s off) before loading onto the nitrocellulose membrane. Human α-synuclein oligomers (Stressmarq, SPR-484) were loaded onto the nitrocellulose membrane without sonication. Equal mass (50 ng) of all proteins

(5) High-molecular-weight oligomer tau (HMWoTau) species are dramatically increased in Braak-stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005)FASEB journal : official publication of the Federation of American Societies for Experimental BiologyNovember 30, 2024Fukumoto H, Kao TH, Tai CY, Jang MK, Miyamoto M.

(6) Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregatesScience AdvancesNovember 17, 2023Rebecca S. Saleeb, Craig Leighton, Ji-Eun Lee, Judi O’Shaughnessy, Kiani Jeacock, Alexandre Chappard, Robyn Cumberland, Tianxiao Zhao, Sarah R. Ball, Margaret Sunde, et al.preformed fibrils are available from a commercial source (StressMarq Biosciences catalog no. SPR-321, SPR-484, and SPR-322, respectively), which are generated using methods previously described. Before oligomerization/fibrilization,

(7) Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrilsbioRxiv : the preprint server for biologyJuly 4, 2023Desai AA, Zupancic JM, Trzeciakiewicz H, Gerson JE, DuBois KN, Skinner ME, Sharkey LM, McArthur N, Ferris SP, Bhatt NN, et al.

(8) LRP1 is a neuronal receptor for α-synuclein uptake and spreadMolecular neurodegenerationSeptember 2, 2022Chen K, Martens YA, Meneses A, Ryu DH, Lu W, Raulin AC, Li F, Zhao J, Chen Y, Jin Y, et al.including human Tau (R&D Systems, SP-495), α-Syn (Proteos, cat# RP-003), oligomeric α-Syn (StressMarq, cat# SPR-484), α-Syn preformed fibrils (PFFs) (StressMarq, cat# SPR-322-C), α-Syn N (1–60) fragment (rPeptide, cat#

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The Role of Oligomeric Alpha Synuclein, Tau, and Amyloid Beta in Neurodegenerative Diseases
Protein oligomers have become essential tools for studying disease pathology. Read More

Alpha Synuclein Oligomers (Kinetically Stable)

Alpha Synuclein Oligomers from StressMarq Biosciences Inc

Description

Sequence

StressMarq Biosciences Inc

Citations (8)

Reviews

Resources

The Role of Oligomeric Alpha Synuclein, Tau, and Amyloid Beta in Neurodegenerative Diseases

Alpha Synuclein Oligomers from StressMarq Biosciences Inc

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