Alpha Synuclein Pre-formed Fibrils SPR-322 from StressMarq Biosciences Inc

Product Specs
ItemAlpha Synuclein Pre-formed Fibrils
CompanyStressMarq Biosciences Inc
Price Supplier Page View Company Product Page
Catalog NumberSPR-322
ApplicationsWB, SDS-PAGE, In vivo assay, In vitro assay
Size100 µg
Research AreaNeuroscience, Neurodegeneration, Alzheimer's Disease, Tangles & Tau, Neuroscience, Neurodegeneration, Parkinson's Disease, Synuclein, Neuroscience, Neurodegeneration, Multiple System Atrophy
NCBI Full Gene Namesynuclein alpha
NCBI Gene AliasesPARK4, NACP, PARK1, PD1
Conjugate/TagNo tag
TypeProtein
Source/Expression SystemE. coli
Purity>95%
SpeciesHuman

Sequence

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Add to Compare List

StressMarq Biosciences Inc

117-1537 Hillside Ave.

Victoria, British Columbia V8T 4Y2

Canada

Phone: +1-250-294-9065
Fax: 1-250-294-9025

Email: info@stressmarq.com

Company Profile

Website: http://www.stressmarq.com

(1) Low-density lipoprotein receptor-related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson's diseaseNeural regeneration researchApril 1, 2026Luo H, Peng C, Wu C, Liu C, Li Q, Yu S, Liu J, Chen M.Biotechnologies (approval No. WD-0312010; July 5, 2017). For the PFF group (n = 3), 600 μg α-syn PFFs (SPR-322, StressMarq, Victoria, Canada) dissolved in 200 μL normal saline were unilaterally injected into the

(2) Assessment of Angiopep-2 targeting intracerebral α-synuclein aggregates in a PFF-induced rat model of Parkinson's disease based on 7T CEST-MRIBrain research bulletinFebruary 19, 2026Lai L, Chen B, Xu L, Wu M, Wang R, Zhuang Z, Dong G, Qi D, Lin K, Li D, et al.

(3) A split biotin ligase approach reveals proteins associated with oligomeric alpha-synuclein during aggregationScientific ReportsFebruary 4, 2026Analiese R. Fernandes, Abigail P. Owen, Ayman H. Faroqi, Jannifer Lee, Gunveen S. Sachdeva, Dmytro Morderer, Cody Hoffmann, Benjamin Madden, Shuwen Zhang, Yingxue Ren, et al.(PFF) preparation and addition PFFs were generated in-house or purchased commercially (Stressmarq, SPR-322 C; in Fig. 1D and E). In-house PFFs were generated using previously described protocols53: recombinant

(4) Glycerol 3-phosphate acyltransferase exacerbates α-synuclein-induced toxicity by increasing lipid peroxidationNature communicationsJanuary 19, 2026Ren M, Lim GGY, Tang W, Lim KL.cortical neurons were treated with 1 μg/ml α-syn monomers (SPR-323, StressMarq) or 1 μg/ml synuclein PFF (SPR-322, StressMarq) with or without 75 μM or 150 μM FSG (HY−112489, MedChemExpress LLC) for 2 weeks. Following

(5) Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathyTranslational psychiatryJanuary 9, 2026Princz-Lebel O, Attaran A, Sandoval Contreras R, Novikov V, Panjwani S, Chu A, Tan C, Lemieux CA, Skirzewski M, Machado MMF, et al.α-synuclein Human aSyn PFF-1 and PFF-2 are available from a commercial source (StressMarq Biosciences Cat# SPR-322 and SPR-317, respectively), which are expressed, purified, and fibrilized using methods previously described

(6) Disrupting α-Synuclein-ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson's disease modelsMol NeurodegenerDecember 22, 2025Di Hu, Xiaoyan Sun, Xin Qi(S-1113-2) were purchased from rPeptide. The human recombinant αSyn pre-formed fibrils (PFF) (Type 1) (SPR-322) and ATTO-594-PFF (SPR-322B-A594) were purchased from StressMarq Biosciences (Bioactivity has been widely

(7) Age-related nigral downregulation of the Parkinson''s risk factor FAM49B primes human microglia for inflammagingNPJ AgingDecember 19, 2025Martin J, Lai GJ, Park CY, West C, Van Brunt T, Ahmed S, Lawal S, Dickson M, Russo T, Akmentin W, et al.

(8) Differential microglial responses to structurally distinct alpha-synuclein polymorphsMolecular BrainDecember 5, 2025Katherine Chang, Jina Kim, Michiyo Iba, Jae-Hyeon Park, Alexandria Beilina, Zulfeqhar A. Syed, Valentina Baena, Liam Horan-Portelance, Mark R. Cookson, Sungyong You, et al.EO), dopamine stabilized α-synuclein oligomers (#SPR-466, DO), and α-synuclein preformed fibrils (#SPR-322, PFF) were purchased from StressMarq Biosciences (Victoria, Canada). To obtain sonicated preformed fibrils

(9) A One-Step Mouse Model of Parkinson’s Disease Combining rAAV-α-Synuclein and Preformed Fibrils of α-SynucleinBIO-PROTOCOLDecember 5, 2025Santhosh Kumar Subramanya, Devendra Singh, Poonam ThakurSimilar PFFs are also available from commercial sources like StressMarq Biosciences (catalog number: SPR-322) and ACROBiosystems (catalog number: ALN-H5115). Reagents 1. Isoflurane I.P. (Sosrane, Neon Laboratories

(10) The G2019S LRRK2 mutation exacerbates α-synuclein and tau neuropathology through divergent pathways in Parkinson's disease modelsActa neuropathologicaNovember 11, 2025Tsafaras G, Cabezudo D, Wetzels L, Tsakogias I, Abey A, Bentea E, Sanchiz-Calvo M, Van den Haute C, Wade-Martins R, Baekelandt V.

(11) Strain-Distinct α-Synuclein and Tau Cross-Seeding Uncovered by Correlative Approach with Optical Photothermal Infrared Sub-Micron ImagingJournal of the American Chemical SocietyAugust 6, 2025Zhan X, Li W, Hatterer E, Courade JP, Piché K, Klementieva O, Li JY.Biosciences (StressMarq Biosciences Inc., British Columbia), specifically, αSyn monomer (SPR-321), αSyn (SPR-322), Tau 0N3R (SPR-491), Tau 2N4R (SPR-480), αS&Tau3R (SPR-494), and αS&Tau4R (SPR-495). The detailed protocol

(12) Leucine-Rich Repeat Kinase 2 Promotes Disintegration of Retinal Pigment Epithelial Cell: Implication in the Pathogenesis of Dry Age-Related Macular DegenerationThe American journal of pathologyJuly 1, 2025Suimon Y, Nishimura M, Murata M, Yoshida S, Yokoi K, Dong Z, Kuno N, Fujii S, Tanei ZI, Yabe I, et al.

(13) The Neurotoxic Properties of α-synuclein PolymorphsExperimental neurobiologyJune 30, 2025Chang K, Syed Z, Baena V, Cookson MR, Kim C.

(14) Alpha-synuclein misfolding as fluid biomarker for Parkinson's disease measured with the iRS platformEMBO molecular medicineJune 1, 2025Schuler M, Gerwert G, Mann M, Woitzik N, Langenhoff L, Hubert D, Duman D, Höveler A, Galkowski S, Simon J, et al.ambient temperature for use within one week. Next to the inhouse-produced fibrils, PFFs type I (Cat. No. SPR-322) from Stressmarq were acquired as reference material for comparison. In addition, human recombinant

(15) Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with α-SynucleinopathyCellsMay 9, 2025Zhylkibayev A, Starr CR, Hossain MI, Kumar S, Andrabi SA, Grant MB, Atigadda VR, Gorbatyuk MS, Gorbatyuk OS.combined injections of AAV-αS and PFFs (AAV/PFF) into the SNpc. The PFFs were purchased from Stressmarq (SPR-322) and the total amount of injected PFFs was 2.5 µg (in 0.5 µL). The AAV containing a blank expression

(16) Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain TissuebioRxivFebruary 14, 2025Louise A. Mesentier-Louro, Camille Goldman, Alain Ndayisaba, Alice Buonfiglioli, Rikki B. Rooklin, Braxton R. Schuldt, Abigail Uchitelev, Vikram Khurana, Joel W. Blanchardof Human Recombinant Alpha Synuclein Protein Aggregates (Pre Formed Fibrils, PFFs, from StressMarq, #SPR-322, or Abcam, #ab218819). PFFs were sonicated in a water bath (VWR Ultrasonic Cleaner) immediately before

(17) Parkinson disease-associated toxic exposures selectively up-regulate vesicular glutamate transporter vGlut2 in a model of human cortical neuronsMolecular biology of the cellFebruary 1, 2025Clark KA, White AJ, Paslawski W, Alexander KD, Peng S, Young-Pearse TL, Svenningsson P, Selkoe DJ, Ho GPH.(SPR-480) PFFs were purchased from StressMarq Biosciences. αS PFFs were either purchased from StressMarq (SPR-322) or generated as described above. αS monomer controls were purchased from StressMarq (SPR-316). On DIV11,

(18) High-molecular-weight oligomer tau (HMWoTau) species are dramatically increased in Braak-stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005)FASEB journal : official publication of the Federation of American Societies for Experimental BiologyNovember 30, 2024Fukumoto H, Kao TH, Tai CY, Jang MK, Miyamoto M.

(19) Exploring the Potential of Biomimetic Peptides in Targeting Fibrillar and Filamentous Alpha-Synuclein-An In Silico and Experimental Approach to Parkinson's DiseaseBiomimetics (Basel, Switzerland)November 18, 2024Frantzeskos SA, Biggs MA, Banerjee IA.

(20) STAT3 Inhibitor Increases α-Synuclein in PFF-Treated Astroglia Cells by Dysregulating Autophagy and Potentially Affects Exosome BiogenesisNeuromolecular medicineNovember 13, 2024Luo Y, Zang N, Tang Y, Chen H, Liu H, Wang L, Xu P.