Description
LILRB1, also known as leukocyte immunoglobulin like receptor B1, is a member of the leukocyte immunoglobulinlike receptor (LIR) family. The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. It is also expressed on the surface of B cells and monocytes, as well as subsets of NK cells, memory/effector CD8+ T cells, gamma delta T cells, and monocyte-derived dendritic cells. It binds to MHC-I as well as non-classical MHC-I molecules and the MHC-I mimetic UL18 encoded by cytomegalovirus. Recombinant human LILRB1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques