Description
CD244 (2B4, SLAMF4) is a 66 kD member of the CD2/SLAM related receptor family (SRR). It is expressed on NK (3), Tcell subsets, monocytes and eosinophils(4). It is expressed at high levels on Leuikemia initiating cells, and plays a role in their proliferative potential (5). In mice there are two transcription varients, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only th long form is expressed.
Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titers(2). CD244 mediated function in immune response can vary greatly dependant on the context of its ligation