Description
Lysine (K)-specific demethylase 2A (KDM2A), also known as FBXL11, JHDM1A, CXXC8, nucleates at CpG islands and specifically demethylates "Lys-36" of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 "Lys-36" residue while it has weak or no activity for mono- and tri-methylated H3 "Lys-36". May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis