Recombinant Human BMP-4 Protein, CF 314-BP-010/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human BMP-4 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $434.00Supplier Page View Company Product Page
Catalog Number314-BP-010/CF
SpeciesHuman
Molecule NameBMP-4
Size10 ug (also 20 ug, 50 ug, 500 ug)
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA
NCBI Full Gene Namebone morphogenetic protein 4
NCBI Gene AliasesMCOPS6, BMP2B1, BMP2B, ZYME, OFC11
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 19-24 kDa, reducing conditions 35-41 kDa, non-reducing conditions
Theoretical: 13 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human BMP-4 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Insulin-stimulated glucose uptake is impaired in senescent human adipocytesFront Endocrinol (Lausanne)March 17, 2026Ida Alexandersson, Henrik Palmgren, Martin Uhrbom, Jan Oscarsson, Jeremie Boucherchanged the following day to PM-1 supplemented with 1 nM bFGF and 15 ng/ml BMP4 (R&D systems, Cat. 314-BP-010/CF). After becoming confluent (usually after 4–5 days), differentiation was initiated by changing the medium

(2) Insulin-stimulated glucose uptake is impaired in senescent human adipocytesFront Endocrinol (Lausanne)March 17, 2026Ida Alexandersson, Henrik Palmgren, Martin Uhrbom, Jan Oscarsson, Jeremie Boucherchanged the following day to PM-1 supplemented with 1 nM bFGF and 15 ng/ml BMP4 (R&D systems, Cat. 314-BP-010/CF). After becoming confluent (usually after 4–5 days), differentiation was initiated by changing the medium

(3) Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cellsFrontiers in ImmunologyFebruary 20, 2026Alexandros Nianias, Afroditi Katsarou, Henk Jan Prins, Aida Shahrabi, Cindy van Velzen, Linda Henneman, Ruud Ruiter, Tuna Mutis, Richard Groen, Maria ThemeliEB formation was facilitated by overnight incubation along with 30 ng/mL rhBMP-4 (R&D Systems, Cat#314-BP-010/CF). Medium was refreshed the next day and EBs were then cultured with 30 ng/mL rhBMP4 and 5 ng/mL hbFGF

(4) BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial HypertensionHypertensionFebruary 1, 2026Clarissa Becher, Esmee J. Groeneveld, Rozenn Quarck, Beau Neep, Xiaoke Pan, Robert Szulcek, Ly Tu, Christophe Guignabert, Harm Jan Bogaard, Paul B. Yu, et al.available from the corresponding author upon reasonable request. Reagents Human recombinant BMP4 (314-BP-010/CF), BMP6 (507-BP-020/CF), BMP9 (3209-BP-010/CF), BMP10 (2926-BP-025/CF), activin A (338-AC-010/CF), TGF-b1

(5) Robust, scalable and xeno-free protocol for differentiating human induced pluripotent stem cells into functional macrophagesFrontiers in ImmunologyJanuary 12, 2026Miquel De Homdedeu, Rubén Escribá, Kenia Rodríguez-González, Sergi Querol, Jesus Fernandez-Sojo, Belén Alvarez-PalomoSTEMdiff™ APEL™2 medium (Stemcell Technologies Cat#5270) supplemented with BMP-4 (20 ng/mL; R&D Systems Cat#314-BP-010/CF), VEGF (200 ng/mL; Stemcell Technologies Cat#78159.1), bFGF (200 ng/mL; Stemcell Technologies Cat#78134.1),

(6) Natural killer cell-specific chimeric antigen receptor enhances CAR NK cell functions and anti-tumor activityTheranosticsNovember 6, 2025Changqing Pan, You Zhai, Zhongliang Cui, Yiyun Yin, Menghui Xu, Di Wang, Yishuo Sun, Jiazheng Zhang, Chen Wang, Ziwei Li, et al.(PeproTech, 300-07-10), 20 ng/mL VEGF (R&D Systems, BT-VEGF-020), and 20 ng/mL BMP-4 (R&D Systems, 314-BP-010/CF). On day 7, EBs were transferred to 6-well plates containing DMEM/F-12 medium (STEMCELL, 10565018) supplemented

(7) Cdh2, a downstream target of Hes7, regulates somitogenesis by supporting FGF signallingDevelopmentSeptember 1, 2025Xueqi Jia, Akihiro Isomura, Ryoichiro Kageyamaof a2i medium, cells were resuspended in NDiff227 medium supplied with 20 ng/ml BMP4 (R&D Systems, 314-BP-010/CF). Then, 2.4x104 cells were plated in each well of a 96-microwell plate (EZSPHERE 96-Well Plate; IWAKI,

(8) Establishment of bovine extraembryonic endoderm cellsbioRxiv : the preprint server for biologyDecember 17, 2024Ming H, Scatolin GN, Ojeda A, Jiang Z.

(9) Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis modelNature communicationsJune 10, 2024Paul SK, Oshima M, Patil A, Sone M, Kato H, Maezawa Y, Kaneko H, Fukuyo M, Rahmutulla B, Ouchi Y, et al.

(10) Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessmentiScienceFebruary 16, 2024Junjun Li, Ying Hua, Yuting Liu, Xiang Qu, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Hayato Miyoshi, Mikio Shiba, et al.Corporation,Cat#012-04802 1-thioglycerol,Sigma-Aldrich,Cat#M1753-100ML Bone morphologic protein 4,R&D Systems,Cat#314-BP-010/CF Activin A,R&D Systems,Cat#338-AC-010/CF Vascular endothelial growth factor (VEGF),FUJIFILM Wako Pure

(11) Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue modelF1000ResearchFebruary 12, 2024Max J Cumberland, Jonas Euchner, Amar J Azad, Nguyen T N Vo, Paulus Kirchhof, Andrew P Holmes, Chris Denning, Katja GehmlichReconstituted in 4 mM HCl (0.1 % BSA) to 50 μg/mL and stored at -80 °C in 5 μL aliquots),"R&D Systems, 314-BP-010/CF" Human Activin A Recombinant Protein ( Reconstituted in PBS (0.1 % BSA) to 10 μg/mL and stored at -20

(12) Applications of Human Pluripotent Stem Cell–Derived Skin Organoids in DermatologyJournal of Investigative DermatologyOctober 1, 2023Aaron Gabriel W. Sandoval, Kelly Y. Gim, Jennifer T. Huang, Karl R. Koehlerinhibitor),Stemgent,04-0010-05,10 μM Recombinant human bFGF,PeproTech,100-18B,4 ng/mL Recombinant human BMP4,R&D Systems,314-BP-010/CF,5 ng/mL Normocin,InvivoGen,Ant-nr-1,100 μg/mL Day 3,,, Components,Vendor,Cat. no.,Final concentration Essential 6 medium

(13) Transcriptional network governing extraembryonic endoderm cell fate choiceDevelopmental biologyOctober 1, 2023Pham PD, Lu H, Han H, Zhou JJ, Madan A, Wang W, Murre C, Cho KWY.17502048). The media was then changed to N2B27 without serum, supplemented with 25 ng/ml BMP4 (R&D Systems, 314-BP-010/CF). Cells are seeded and harvested at Day 1 (24h) and Day 3 (72h) for RNA-seq. RNA-seq Total RNA was

(14) Identification of ligand-receptor pairs that drive human astrocyte developmentNature neuroscienceAugust 1, 2023Voss AJ, Lanjewar SN, Sampson MM, King A, Hill EJ, Sing A, Sojka C, Bhatia TN, Spangle JM, Sloan SA.R&D Systems, Cat. 5439-DK-010/CF, 100 ng/uL), and BMP4 (Sigma-Aldrich, Cat. H4916–10UG, R&D Systems, Cat. 314-BP-010/CF, 20 ng/uL). RNA-Sequencing Library Preparation Following exposures, total RNA was extracted from organoids

(15) Cell-free DNA as a potential biomarker of differentiation and toxicity in cardiac organoidseLifeJune 1, 2023Silver B, Gerrish K, Tokar E.1x B27 (no insulin; Gibco, A18956-01), CHIR 99021 (4 µM; Selleck, S2924), BMP4 (0.36 pM; BioTechne, 314BP-010/CF), and ActA (0.08 pM; BioTechne, 338-AC-010/CF). On day 1, 166 µL of media was removed and replaced with

(16) The time integral of BMP signaling determines fate in a stem cell model for early human developmentbioRxiv : the preprint server for biologyApril 10, 2023Teague S, Primavera G, Chen B, Freeburne E, Khan H, Jo K, Johnson C, Heemskerk I.

(17) Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cellsCell reportsMarch 28, 2023Li S, Wang CS, Montel-Hagen A, Chen HC, Lopez S, Zhou O, Dai K, Tsai S, Satyadi W, Botero C, et al.

(18) hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's diseaseCell stem cellMarch 2, 2023Fan Y, Hackland J, Baggiolini A, Hung LY, Zhao H, Zumbo P, Oberst P, Minotti AP, Hergenreder E, Najjar S, et al.

(19) Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methodsRegenerative therapyMarch 1, 2023Liu Q, Liu Z, Gu H, Ge Y, Wu X, Zuo F, Du Q, Lei Y, Wang Z, Lin H.

(20) Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signalingScientific reportsFebruary 23, 2023Shono M, Kishimoto K, Hikabe O, Hayashi M, Semi K, Takashima Y, Sasaki E, Kato K, Hayashi K.

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Recombinant Human BMP-4 Protein, CF

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Recombinant Human BMP-4 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human BMP-4 Protein, CF from R&D Systems, a Bio-Techne Brand

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