R-Spondin 1 Protein 4645-RS-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemR-Spondin 1 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $408.00Supplier Page View Company Product Page
Catalog Number4645-RS-025
SpeciesHuman
Size25 ug (also 100 ug, 250 ug, 1 mg)
Source/Expression SystemCHO-derived Recombinant Human R-Spondin 1 Protein
Molecule NameR-Spondin 1
NCBI Full Gene NameR-spondin 1
NCBI Gene AliasesRSPO, CRISTIN3
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 25 ug (also 100 ug, 250 ug, 1 mg)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(21) Mesothelioma-Associated Fibroblasts Modulate the Response of Mesothelioma Patient-Derived Organoids to Chemotherapy via Interleukin-6International journal of molecular sciencesMay 14, 2024Cioce M, Gatti V, Napolitano F, Giorgiano NM, Marra A, Portella G, Fiorelli A, Pentimalli F, Fazio VM.

(22) p53 promotes revival stem cells in the regenerating intestine after severe radiation injuryNature communicationsApril 8, 2024Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis II, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, et al.

(23) Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsivenessbioRxiv : the preprint server for biologyMarch 6, 2024Jang KK, Ercelen D, Cen Feng JYC, Gurunathan S, Zhou C, Korman A, Newell L, Hudesman D, Jones DR, Loke P, et al.

(24) Trophoblast organoids with physiological polarity model placental structure and functionJournal of cell scienceMarch 1, 2024Yang L, Liang P, Yang H, Coyne CB.

(25) Effects of Fc glycosylation on the activity of WNT mimetic agonistic antibodiesAntibody TherapeuticsJanuary 18, 2024Hui Chen, Sung-Jin Lee, Brian Ouyang, Nicholas Suen, Jay Ye, Chenggang Lu, Yang Lirecombinant human Noggin (Peprotech Cat# 120-10C) and 500 ng/mL recombinant human R-Spondin 1 (R&D Systems Cat# 4645-RS-025)) with 1 μM IWP2. Media and treatments were changed once on Day 5 after plating. Images were acquired

(26) Automated, High‐Throughput Phenotypic Screening and Analysis Platform to Study Pre‐ and Post‐Implantation Morphogenesis in Stem Cell‐Derived Embryo‐Like StructuresAdvanced ScienceJanuary 1, 2024Vinidhra Shankar, Clemens van Blitterswijk, Erik Vrij, Stefan Giselbrechtµm IWR‐1‐endo,Wnt/Catenin Inhibitor,StemCell Technologies 72562,2.5 µm Rspondin,Wnt receptor Activator,R&D Systems 4645‐RS‐025,100 ng mL−1 SB431542 (SB43),Tgfβ (ALK) Inhibitor,Abcam ab120163,10 µm PD0325901 (PD032),MEK/ERK Inhibitor,Bio‐Techne

(27) Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironmentNature communicationsNovember 30, 2023Li N, Zhu Q, Tian Y, Ahn KJ, Wang X, Cramer Z, Jou J, Folkert IW, Yu P, Adams-Tzivelekidis S, et al.recombinant mouse EGF (Thermo Fisher Scientific, PMG8041), 1 ug/ml recombinant human R-spondin1 (R&D, 4645-RS-025), 500 nM A83-01 (Tocris, 2939),10 uM SB 202190 (Sigma-Aldrich, S7067-5MG). The organoids were passaged

(28) Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screeningBMC medicineSeptember 4, 2023Luo Z, Wang B, Luo F, Guo Y, Jiang N, Wei J, Wang X, Tseng Y, Chen J, Zhao B, et al.

(29) Persistent organic pollutants promote aggressiveness in prostate cancerOncogeneSeptember 1, 2023Buñay J, Kossai M, Damon-Soubeyrant C, De Haze A, Saru JP, Trousson A, de Joussineau C, Bouchareb E, Kocer A, Vialat M, et al.

(30) GSK3α Regulates Temporally Dynamic Changes in Ribosomal Proteins upon Amino Acid Starvation in Cancer CellsInternational journal of molecular sciencesAugust 26, 2023Loxha L, Ibrahim NK, Stasche AS, Cinar B, Dolgner T, Niessen J, Schreek S, Fehlhaber B, Forster M, Stanulla M, et al.

(31) Patterning and folding of intestinal villi by active mesenchymal dewettingbioRxiv : the preprint server for biologyAugust 15, 2023Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, et al.

(32) Genetic characterization of a novel organoid from human malignant giant-cell tumorJournal of bone oncologyAugust 1, 2023Suzuki R, Wakamatsu T, Yoshida K, Matsuoka Y, Takami H, Nakai S, Tamiya H, Kakunaga S, Yagi T, Yoshida KI, et al.

(33) Generating human blastoids modeling blastocyst-stage embryos and implantationNature protocolsMay 1, 2023Heidari Khoei H, Javali A, Kagawa H, Sommer TM, Sestini G, David L, Slovakova J, Novatchkova M, Scholte Op Reimer Y, Rivron N.120-10C) R-spondin conditioned medium (homemade), or recombinant R-spondin 1 protein (R&D Systems, cat. no. 4645-RS-025) SB202190 (MedChemExpress, cat. no. HY-10295) Insulin-Transferrin-Selenium (ITS) (in house) or (Gibco,

(34) p53 promotes revival stem cells in the regenerating intestine after severe radiation injurybioRxiv : the preprint server for biologyApril 28, 2023Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis I, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, et al.

(35) Targeting TBK1 to overcome resistance to cancer immunotherapyNatureMarch 1, 2023Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, et al.

(36) Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated PlatesInternational journal of molecular sciencesFebruary 16, 2023Nomura M, Yokoyama Y, Yoshimura D, Minagawa Y, Yamamoto A, Tanaka Y, Sekiguchi N, Marukawa D, Ichihara M, Itakura H, et al.

(37) Combined PD-1, BRAF and MEK inhibition in BRAF(V600E) colorectal cancer: a phase 2 trialNature medicineFebruary 1, 2023Tian J, Chen JH, Chao SX, Pelka K, Giannakis M, Hess J, Burke K, Jorgji V, Sindurakar P, Braverman J, et al.

(38) Generation and cryopreservation of feline oviductal organoidsTheriogenologyJanuary 15, 2023Thompson RE, Meyers MA, Premanandan C, Hollinshead FK.

(39) Disentangling the innate immune responses of intestinal epithelial cells and lamina propria cells to Salmonella Typhimurium infection in chickensFrontiers in microbiologyJanuary 1, 2023Sutton K, Nash T, Sives S, Borowska D, Mitchell J, Vohra P, Stevens MP, Vervelde L.

(40) 3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinomaJ Clin InvestDecember 15, 2022Ya’an Kang, Jenying Deng, Jianhua Ling, Xinqun Li, Yi-Ju Chiang, Eugene J. Koay, Huamin Wang, Jared K. Burks, Paul J. Chiao, Mark W. Hurd, et al.A83-01, and Nicotinamide were purchased from R&D Systems (catalog 236-EG-200, 345-FG-025, 6057-NG-025, 4645-RS-025, 3006/1, 1254/1, 2939/10, and 4106/50, respectively). Nicotinamide was purchased from Sigma-Aldrich

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Recombinant Human R-Spondin 1 Protein

R-Spondin 1 Protein

R-Spondin 1 Protein

R-Spondin 1 Protein

R-Spondin 1 Protein

R-Spondin 1 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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R-Spondin 1 Protein from R&D Systems, a Bio-Techne Brand

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