Microcystin-LR 10007188 from Cayman Chemical

Product Specs
ItemMicrocystin-LR
CompanyCayman Chemical
Price $609.00Supplier Page View Company Product Page
Catalog Number10007188
Size1 mg
FormatA solid
Molecular Weight995.2
Purity≥95%
Research AreaAquatic, Cell Biology, Cell Signaling, Environmental Toxicology, Hepatotoxicity, Organ- & System-Specific Toxicity, Toxic Agents, Toxicology & Xenobiotic Metabolism, Toxins
Storage-20
FormulaC49H74N10O12
OriginTWN
Source/Expression SystemBacterium/Microcystis aeruginosa

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Transporter-Mediated Uptake of Microcystin-LR in Human Trophoblasts: Regulation By Oxygen Concentration and Cell FusionbioRxivMarch 27, 2026Michael Jeffrey Campbell, Mokshitkumar Patel, Chenghui Jiang, Xia Wen, Shuo Xiao, Lauren M. Aleksunesconditions such as oxygen concentration and cell fusion. Methods Chemicals: MC-LR (Cayman Chemicals Cat #10007188, Purity >95%) was purchased in large quantities to ensure the same lot number (Batch 0669496–1) was

(2) Revisiting phosphoregulation of Cdc25C during M-phase inductioniScienceJanuary 17, 2025Tan Tan, Chuanfen Wu, Ruoning Wang, Bih-Fang Pan, David Hawke, Fumin Yin, Zehao Su, Boye Liu, Sue-Hwa Lin, Wei Zhang, et al.Tris-HCl (pH 7.5), 10 mM MgCl2, 5 mM β-glycerophosphate, 1 μM microcystin (MC) (Cayman Chemical Company, 10007188), 1 mM ATP, 1 mM DTT, and 1x protease inhibitor cocktail. The TNT-produced 4 kinase mix was produced

(3) Cyanobacterial Cultures, Cell Extracts, and Individual Toxins Decrease Photosynthesis in the Terrestrial Plants Lactuca sativa and Zea maysPlants (Basel)November 13, 2024Scott A. Heckathorn, Clare T. Muller, Michael D. Thomas, Emily P. Vining, Samantha Bigioni, Clair Elsie, J. Thomas Franklin, Emily R. New, Jennifer K. Boldtdeionized water (1 μM ANA, BMAA, MC or 50 µg mL−1 LPS) (experiment 7) [ANA/BMAA/MC-LR (products 14609/2387/10007188) from Cayman Chemical, Ann Arbor, MI, USA; LPS from E. coli (product L2630) from Sigma-Aldrich, St.

(4) Synthesis of a Truncated Microcystin Tetrapeptide Molecule from a Partial Mcy Gene Cluster in Microcystis Cultures and BloomsEnvironmental Science & TechnologyNovember 12, 2024Colleen E. Yancey, Lauren Hart, Apurva Chandrakant Lad, Johnna A. Birbeck, Siliang Song, Osama G. Mohamed, Andrew M. Fribley, Steven T. Haller, Ashootosh Tripathi, David J. Kennedy, et al.hrs. For exposure to the tetrapeptides and their appropriate controls, lyophilized MC-LR (Cat. No. 10007188, Cayman Chemicals, MI, USA) was dissolved in 1 ml of Ultrapure Distilled water (Cat. No. 10977–015,

(5) Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Type 1/Type 17 Inflammation of Murine AirwaysToxins (Basel)November 1, 2024Joshua D. Breidenbach, Benjamin W. French, Lauren M. Stanoszek, John-Paul Lavik, Krishna Rao Maddipati, Sanduni H. Premathilaka, David Baliu-Rodriguez, Bivek Timalsina, Vaishnavi Aradhyula, Shivani C. Patel, et al.Committee (IACUC protocol #108663, approval date 9 February 2016). Mice were exposed to MC-LR (item no. 10007188; Cayman Chemical, Ann Arbor, MI, USA) aerosol or vehicle (water or saline) aerosol using an inExpose

(6) Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG CellsInternational Journal of Molecular SciencesJuly 6, 2023Katherine D. Lynch, Dayne T. Iverson, Namrata K. Bachhav, Michael Ridge Call, Guihua Eileen Yue, Bhagwat Prasad, John D. Clarkeand trypsin (cat. 90057) were purchased from Thermo Fisher Scientific (Waltham, MA, USA). MCLR (cat. 10007188, ≥95% purity) was purchased from Cayman Chemicals (Ann Arbor, MI, USA). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium

(7) Effects of Cyanobacterial Harmful Algal Bloom Toxin Microcystin-LR on Gonadotropin-Dependent Ovarian Follicle Maturation and Ovulation in MiceEnvironmental health perspectivesJune 1, 2023Wang Y, Pattarawat P, Zhang J, Kim E, Zhang D, Fang M, Jannaman EA, Yuan Y, Chatterjee S, Kim JJ, et al.cage. Long-Term Low-Dose Oral Exposure to MC-LR in Vivo In this study, we administered MC-LR (item no. 10007188; Cayman Chemicals) to 4-wk-old young adult CD-1 female mice by oral gavage at 10μg/kg per day for 6

(8) Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulatorsMolecular biology of the cellOctober 1, 2022Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, et al.of 50 mM Tris-HCl, pH 7.5, 10 mM MgCl2, 5 mM β-glycerophosphate, 1 µM MC (Cayman Chemical Company, 10007188), 1 mM DTT, and 1× protease inhibitor cocktail (Roche). Note that the addition of exogenous ATP did

(9) Antioxidant Therapy Significantly Attenuates Hepatotoxicity following Low Dose Exposure to Microcystin-LR in a Murine Model of Diet-Induced Non-Alcoholic Fatty Liver DiseaseAntioxidants (Basel)August 22, 2022Apurva Lad et al.water equivalent to that of the MC-LR exposed mice (300 µL); Group 2 was gavaged with MC-LR (Cat. No. 10007188, Cayman Chemicals, Ann Arbor, MI, USA) at 100 µg/kg of body weight; Group 3 was exposed to 100 µg/kg

(10) A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their InteractorsJournal of Visualized ExperimentsMay 16, 2022Kali A. Smolen, Arminja N. Kettenbachflammable and toxic; wear gloves, and work in a chemical fume hood." Microcystin LR (MCLR),Cayman Chemical,10007188,CAUTION: MCLR is toxic; wear gloves when handling and avoid skin contact. "PBS, 1× without calcium

(11) MCLR-elicited hepatic fibrosis and carcinogenic gene expression changes persist in rats with diet-induced nonalcoholic steatohepatitis through a 4-week recovery periodToxicologyDecember 1, 2021Arman T, Baron JA, Lynch KD, White LA, Aldan J, Clarke JD.were administered vehicle (0.9% saline, 0.09% ethanol; 5 mL/kg) or MCLR (30 μg/kg; 5 mL/kg; Catalog# 10007188 Cayman Chemicals, Ann Arbor, MI, USA) via intraperitoneal injections (n=18 per diet and treatment group)

(12) Affinity-based profiling of endogenous phosphoprotein phosphatases by mass spectrometryNature ProtocolsOctober 1, 2021Brooke L. Brauer, Kwame Wiredu, Sierra Mitchell, Greg B. Moorhead, Scott A. Gerber, Arminja N. Kettenbachhydrochloride) (Millipore-Sigma, cat. no. M6500) Microcystin LR (MCLR, Cayman Chemical, cat. no. 10007188) CAUTION: MCLR is toxic, wear gloves when handling. 95% Ethanol (v/v) (Sigma Aldrich, cat. no. 652261)

(13) Microcystin-LR (MC-LR) Triggers Inflammatory Responses in MacrophagesInternational Journal of Molecular SciencesSeptember 14, 2021Robin C. Su et al.or 3% DSS in water ad libitum for 7 days. Then, mice were given water or 1000 μg/kg MC-LR (item no. 10007188; Cayman Chemical, Ann Arbor, MI, USA) daily for 7 days by oral gavage. This yielded 4 groups: Water-only

(14) Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growthJCI insightMay 10, 2021Shuhaibar LC, Kaci N, Egbert JR, Horville T, Loisay L, Vigone G, Uliasz TF, Dambroise E, Swingle MR, Honkanen RE, et al.in 250 μL of 1% SDS containing 10 mM sodium fluoride, 1 μM microcystin-LR (Cayman Chemical, catalog 10007188), and protease inhibitor cocktail (Roche, catalog 04 693 159 001). Protein content was determined by

(15) The Use of Mononucleosome Immunoprecipitation for Analysis of Combinatorial Histone Post-translational Modifications and Purification of Nucleosome-Interacting ProteinsFrontiers in cell and developmental biologyJanuary 1, 2020Khan KA, Ng MK, Cheung P.M9272)Micrococcal Nuclease (Worthington Biochem, cat. no. LS004798)Microcystin-LR (Cayman, cat. no. 10007188)NaCl (Fisher BioReagents, cat. no. BP358)N-ethylmaleimide (NEM; Sigma-Aldrich, cat. no. E3876)Pepstatin

(16) Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver DiseaseToxins (Basel)August 23, 2019Apurva Lad et al.consisted of Leprdb/J mice that were exposed to 50 μg/kg and 100 μg/kg of body weight of MC-LR (Item No. 10007188, Cayman Chemicals, Ann Arbor, MI, USA) respectively. MC-LR or vehicle control was administered to the

(17) Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switchNature communicationsDecember 17, 2015Qian J, Beullens M, Huang J, De Munter S, Lesage B, Bollen M.Laboratories), Hesperadin (S1529, Selleckchem), Monastrol (orb146117, Biorbyt) and Microcystin-LR (10007188, Cayman) were purchased. Duplexes of siRNA against RepoMan (TGACAGACTTGACCAGAAA) and control siRNA (TAAGGCTATGAAGAGATAC)

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Microcystin-LR from Cayman Chemical

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Cayman Chemical

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Microcystin-LR from Cayman Chemical

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