Description
An isomer of linoleic acid; has been found in bovine milk products; binds to PPARα (IC50 = 200 nM) and activates PPARα in a reporter assay using COS-1 cells expressing the mouse receptor; inhibits stearoyl-CoA desaturase activity in mouse liver microsomes and TRAP activity in media from primary human CD14+ monocytes; induces apoptosis in LoVo and HT-29 colon cancer cells at 100 µM; reduces epididymal, perirenal, and subcutaneous white adipose tissue weights in hamsters fed an atherogenic diet