Mca-SEVNLDAEFRK(Dnp)RR-NH2 Fluorogenic Peptide Substrate ES004 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMca-SEVNLDAEFRK(Dnp)RR-NH2 Fluorogenic Peptide Substrate
CompanyR&D Systems, a Bio-Techne Brand
Price $337.00Supplier Page View Company Product Page
Catalog NumberES004
Size1 mg
ApplicationsBioactivity
SpeciesMulti-Species
Molecule NameProtease Substrates
StorageSamples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light

Specifications/Features

Available conjugates: Sizes Available: 1 mg

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Inhibition of Amyloid β Accumulation by Protease-Digested Whitebait (Shirasu) in a Murine Model of Alzheimer’s DiseaseFoodsSeptember 10, 2024Takahiro Katsuki, Kayako Ogi, Ayaka Kinno, Shingo Kasamatsu, Hideshi Ihara, Hidenobu Sumitanidissolved in ultrapure water, and fluorescent peptide substrate IV (Mca-SEVNLDAEFRK(DNP)RR-NH2; Cat#ES004, R&D Systems) was dissolved in dimethyl sulfoxide (DMSO). They were diluted with 0.1 M sodium acetate

(2) Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer's Disease: From In Silico to In VivoInternational journal of molecular sciencesOctober 28, 2022Stern N, Gacs A, Tátrai E, Flachner B, Hajdú I, Dobi K, Bágyi I, Dormán G, Lőrincz Z, Cseh S, et al.contained 1% DMSO in 100 mM sodium acetate, pH 4.0. The peptide substrate was purchased from R&D Systems (ES004), and we used a final concentration of 10 µM. The enzyme was also purchased from R&D Systems (931-AS-050)

(3) Mucin-Type O-Glycosylation Proximal to Î²-Secretase Cleavage Site Affects APP Processing and Aggregation FateFrontiers in ChemistryApril 8, 2022YashoNandini Singh, Deepika Regmi, David Ormaza, Ramya Ayyalasomayajula, Nancy Vela, Gustavo Mundim, Deguo Du, Dmitriy Minond, MarÃ© Cudic(MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(DPN)-Arg-Arg-NH2) were from R&D Systems (catalog #ES004 and #931-AS, respectively). Synthesis of APP (Glyco)peptides All peptide analogs of APP were synthesized

(4) Tyrosine O-GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model GlycopeptidesACS Chemical NeuroscienceAugust 18, 2021YashoNandini Singh, David Ormaza, Alessandra Massetti, Dmitriy Minond, Maré Cudic(MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(DPN)-Arg-Arg-NH2) were from R&D Systems (catalog #ES004 and #931-AS, respectively). Recombinant human ADAM10 and ADAM10 substrate (Mca-KPLGL-Dpa-AR-NH2) were

(5) The botanical origin and antioxidant, anti-BACE1 and antiproliferative properties of bee pollen from different regions of South KoreaBMC complementary medicine and therapiesJuly 25, 2020Zou Y, Hu J, Huang W, Zhu L, Shao M, Dordoe C, Ahn YJ, Wang D, Zhao Y, Xiong Y, et al.

(6) Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP CleavageJournal of molecular biologyMay 25, 2018Campagna J, Vadivel K, Jagodzinska B, Jun M, Bilousova T, Spilman P, John V.

(7) Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavageProceedings of the National Academy of Sciences of the United States of AmericaFebruary 7, 2017Netzer WJ, Bettayeb K, Sinha SC, Flajolet M, Greengard P, Bustos V.

(8) Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing PathwayJournal of Alzheimer's disease : JADJanuary 1, 2017Fisher CL, Resnick RJ, De S, Acevedo LA, Lu KP, Schroeder FC, Nicholson LK.Recombinant Human BACE1 protein, CF (931-AS) and Mca-SEVNLDAEFRK(Dnp)RR-NH2 Fluorogenic Peptide Substrate (ES004) were acquired from R&D Systems (Minneapolis, MN); the BACE1 inhibitor LY2811376 was purchased from

(9) Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated MembranesJournal of Alzheimer's disease : JADJanuary 1, 2017Del Prete D, Suski JM, Oulès B, Debayle D, Gay AS, Lacas-Gervais S, Bussiere R, Bauer C, Pinton P, Paterlini-Bréchot P, et al.

(10) Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor proteinJournal of neurochemistryJune 1, 2007Na CH, Jeon SH, Zhang G, Olson GL, Chae CB.

(11) BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitorsThe Journal of biological chemistryJuly 11, 2003Andrau D, Dumanchin-Njock C, Ayral E, Vizzavona J, Farzan M, Boisbrun M, Fulcrand P, Hernandez JF, Martinez J, Lefranc-Jullien S, et al.

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Mca-SEVNLDAEFRK(Dnp)RR-NH2 Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (11)

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Mca-SEVNLDAEFRK(Dnp)RR-NH2 Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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