Recombinant Mouse Complement Component C5a Protein, CF 2150-C5-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse Complement Component C5a Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $428.00Supplier Page View Company Product Page
Catalog Number2150-C5-025/CF
SpeciesMouse
ProteinComplement Component C5a
Quantity25 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
NCBI Full Gene Namehemolytic complement
NCBI Gene AliasesHfib2, C5a, C5, He
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight9.0 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Mouse Complement Component C5a Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Non-cell-autonomous tumor promotion in DICER1 cancer predispositionDevelopmental CellJanuary 14, 2026Randolph K. Larsen, Jason A. Hanna, Hongjian Jin, Kristin B. Reed, Darden W. Kimbrough, Kyna Vuong, Jongchan Hwang, Grace E. Adkins, Jack D. Hopkins, Bradley T. Stevens, et al.cell-culture incubator to allow settling. Next, the cells were treated with 100 nM Complement Component C5a (#2150-C5–025/CF, Bio-techne) or vehicle (PBS) and incubated for two hours at 37 °C in a cell-culture incubator. Cells

(2) Neutrophil-activating therapy for the treatment of cancerCancer cellFebruary 13, 2023Linde IL, Prestwood TR, Qiu J, Pilarowski G, Linde MH, Zhang X, Shen L, Reticker-Flynn NE, Chiu DK, Sheu LY, et al.IL-1β,BioLegend,Cat# 575102 Recombinant mouse IL-17A,BioLegend,Cat# 576002 Recombinant mouse C5a,R&D Systems,Cat# 2150-C5-025/CF Recombinant human TNF,BioLegend,Cat# 570104 Recombinant human C5a,R&D Systems,Cat# 2037-C5-025/CF Cobra

(3) Investigation into the anti-airway inflammatory role of the PI3Kγ inhibitor JN-PK1: An in vitro and in vivo studyInternational immunopharmacologyOctober 1, 2022Xiong W, Jia L, Liang J, Cai Y, Chen Y, Nie Y, Jin J, Zhu J.

(4) Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cellsJournal of neuroinflammationJuly 14, 2022Llorián-Salvador M, Byrne EM, Szczepan M, Little K, Chen M, Xu H.

(5) Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactionsCell death & diseaseMay 25, 2022Brandolini L, d'Angelo M, Novelli R, Castelli V, Giorgio C, Sirico A, Cocchiaro P, D'Egidio F, Benedetti E, Cristiano C, et al.

(6) Heme catabolism by tumor-associated macrophages controls metastasis formationNature immunologyMay 1, 2021Consonni FM, Bleve A, Totaro MG, Storto M, Kunderfranco P, Termanini A, Pasqualini F, Alì C, Pandolfo C, Sgambelluri F, et al.

(7) Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degenerationJournal of neuroinflammationNovember 25, 2020Little K, Llorián-Salvador M, Tang M, Du X, Marry S, Chen M, Xu H.cultured in 10% FCS were treated with 10 ng/ml recombinant mouse C3a (Cat No: 8085-C3) or C5a (Cat No: 2150-C5-025/CF) for 48–96 h. Ten nanograms per milliliter of TGF-β1 (Cat No: 7666-MB-005) (all from R&D Systems, Abingdon,

(8) Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxisThe Journal of biological chemistryMay 29, 2020van den Bos E, Ambrosy B, Horsthemke M, Walbaum S, Bachg AC, Wettschureck N, Innamorati G, Wilkie TM, Hanley PJ.

(9) Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophilsThe Journal of biological chemistryApril 24, 2020Schmider AB, Bauer NC, Sunwoo H, Godin MD, Ellis GE, Lee JT, Nigrovic PA, Soberman RJ.

(10) C3a elicits unique migratory responses in immature low-density neutrophilsOncogeneMarch 1, 2020Hsu BE, Roy J, Mouhanna J, Rayes RF, Ramsay L, Tabariès S, Annis MG, Watson IR, Spicer JD, Costantino S, et al.

(11) Macrophage centripetal migration drives spontaneous healing process after spinal cord injuryScience advancesMay 1, 2019Kobayakawa K, Ohkawa Y, Yoshizaki S, Tamaru T, Saito T, Kijima K, Yokota K, Hara M, Kubota K, Matsumoto Y, et al.

(12) The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4Scientific reportsMarch 14, 2019Funk N, Munz M, Ott T, Brockmann K, Wenninger-Weinzierl A, Kühn R, Vogt-Weisenhorn D, Giesert F, Wurst W, Gasser T, et al.

(13) A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritisNature immunologyFebruary 1, 2019Arandjelovic S, Perry JSA, Lucas CD, Penberthy KK, Kim TH, Zhou M, Rosen DA, Chuang TY, Bettina AM, Shankman LS, et al.

(14) Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitroFrontiers in cellular neuroscienceJanuary 1, 2019Muth C, Hartmann A, Sepulveda-Falla D, Glatzel M, Krasemann S.

(15) C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in miceEuropean journal of immunologyApril 1, 2018Syed SN, Rau E, Ziegelmann M, Sogkas G, Brüne B, Schmidt RE.

(16) Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular DegenerationInvestigative ophthalmology & visual scienceFebruary 1, 2018Toomey CB, Landowski M, Klingeborn M, Kelly U, Deans J, Dong H, Harrabi O, Van Blarcom T, Yeung YA, Grishanin R, et al.

(17) Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal ModelsInvestigative ophthalmology & visual scienceFebruary 1, 2018Crowley MA, Delgado O, Will-Orrego A, Buchanan NM, Anderson K, Jaffee BD, Dryja TP, Liao SM.

(18) Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease TreatmentMBioJanuary 23, 2018Herrmann JB, Muenstermann M, Strobel L, Schubert-Unkmeir A, Woodruff TM, Gray-Owen SD, Klos A, Johswich KO.

(19) Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of TregScientific reportsJune 15, 2017Wang Y, Lai P, Chen X, He C, Huang X, Geng S, Luo C, Wu S, Ling W, Zhong L, et al.

(20) The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1Journal of immunology (Baltimore, Md. : 1950)April 1, 2017Markiewski MM, Vadrevu SK, Sharma SK, Chintala NK, Ghouse S, Cho JH, Fairlie DP, Paterson Y, Astrinidis A, Karbowniczek M.

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Complement Component C5a Protein

Complement Component C5a Protein

Complement Component C5a Protein

Complement Component C5a Protein

Complement Component C5a Protein

Recombinant Mouse Complement Component C5a Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse Complement Component C5a Protein, CF from R&D Systems, a Bio-Techne Brand

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