Recombinant Mouse Complement Component C5a Protein 2150-C5-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse Complement Component C5a Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $428.00Supplier Page View Company Product Page
Catalog Number2150-C5-025
SpeciesMouse
Source/Expression SystemE. coli-derived Recombinant Mouse Complement Component C5a Protein
Quantity25 ug
ProteinComplement Component C5a
NCBI Full Gene Namehemolytic complement
NCBI Gene AliasesHfib2, C5a, C5, He
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight9.0 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) C5a-Induced Autophagy Dysfunction Promotes Choroidal Neovascularization Through the ROS-Inflammatory PathwayInvestigative ophthalmology & visual scienceJuly 1, 2025Du Y, Feng L, Tang J, Qin X, Bai B, Liang L.serum and 1% penicillin/streptomycin.14 Reagents and Antibodies The C5a (2037-C5-025 for humans and 2150-C5-025 for mice) was procured from R&D Systems (Minneapolis, MN, USA). Rapamycin (R0395), rotenone (R8875),

(2) The C5a/C5aR1 Axis Promotes Migration of Tolerogenic Dendritic Cells to Lymph Nodes, Impairing the Anticancer Immune ResponseCancer immunology researchMarch 4, 2025Senent Y, Remírez A, Repáraz D, Llopiz D, Celias DP, Sainz C, Entrialgo-Cadierno R, Suarez L, Rouzaut A, Alignani D, et al.

(3) Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signalingNat CommunFebruary 7, 2025Jeonghyeon Kwon, Haruya Kawase, Kenny Mattonet, Stefan Guenther, Lisa Hahnefeld, Jamal Shamsara, Jan Heering, Michael Kurz, Sina Kirchhofer, Cornelius Krasel, et al.20110), PGE2 for FRET experiments (14010) were from Cayman chemical company. Complement component C5a (2150-C5-025) was from R&D systems. CXCL1 (573704) and CXCL3 (590802) were from Biolegend. Decoy peptides were synthesized

(4) Active immunotherapy for C5a-mediated inflammation using adjuvant-free self-assembled peptide nanofibersActa biomaterialiaApril 15, 2024Hainline KM, Haddad HF, Gilpin A, Curvino EJ, Varghese S, Collier JH.methods [13]. Plates were coated with 20 μg/mL peptide epitopes or 5 μg/mL murine C5a or C5 (R&D Systems 2150-C5–025 and Abcam ab151847, respectively) in PBS overnight at 4 °C. Background wells were coated with the same

(5) Inflammatory mediators act at renal pericytes to elicit contraction of vasa recta and reduce pericyte density along the kidney medullary vascular networkFrontiers in physiologyJanuary 1, 2023Lilley RJ, Taylor KD, Wildman SSP, Peppiatt-Wildman CM.

(6) Investigation into the anti-airway inflammatory role of the PI3Kγ inhibitor JN-PK1: An in vitro and in vivo studyInternational immunopharmacologyOctober 1, 2022Xiong W, Jia L, Liang J, Cai Y, Chen Y, Nie Y, Jin J, Zhu J.

(7) Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cellsJournal of neuroinflammationJuly 14, 2022Llorián-Salvador M, Byrne EM, Szczepan M, Little K, Chen M, Xu H.No.,Company "Recombinant Mouse Complement C3a, CF",8085-C3,R&D Systems Recombinant Mouse Complement C5a,2150-C5-025,R&D Systems Recombinant Mouse TGF-β2,7346-B2-005,R&D Systems PMX 53 (C5a receptor antagonist),Cat.

(8) Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactionsCell death & diseaseMay 25, 2022Brandolini L, d'Angelo M, Novelli R, Castelli V, Giorgio C, Sirico A, Cocchiaro P, D'Egidio F, Benedetti E, Cristiano C, et al.

(9) Heme catabolism by tumor-associated macrophages controls metastasis formationNature immunologyMay 1, 2021Consonni FM, Bleve A, Totaro MG, Storto M, Kunderfranco P, Termanini A, Pasqualini F, Alì C, Pandolfo C, Sgambelluri F, et al.

(10) PI3Kγ Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition—Moving Towards Cell Specific PI3K Targeting?Frontiers in ImmunologyOctober 28, 2020Julie R. Jin, Elena Gogvadze, Ana R. Xavier, Thomas Bohnacker, Jan Voelzmann, Matthias P. WymannGlucose. Stimulation with 4 µM adenosine (Sigma 01890) or 10 nM murine recombinant C5a (R&D Systems 2150-C5-025) was terminated after 2 min by placing tubes on ice, spinning down, and removing supernatant. Subsequently

(11) Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxisThe Journal of biological chemistryMay 29, 2020van den Bos E, Ambrosy B, Horsthemke M, Walbaum S, Bachg AC, Wettschureck N, Innamorati G, Wilkie TM, Hanley PJ.

(12) Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophilsThe Journal of biological chemistryApril 24, 2020Schmider AB, Bauer NC, Sunwoo H, Godin MD, Ellis GE, Lee JT, Nigrovic PA, Soberman RJ.

(13) Macrophage Migration and Phagocytosis Are Controlled by Kindlin-3's Link to the CytoskeletonJournal of immunology (Baltimore, Md. : 1950)April 1, 2020Liu H, Zhu L, Dudiki T, Gabanic B, Good L, Podrez EA, Cherepanova OA, Qin J, Byzova TV.for 1 hour, and treated with or without 20 ng/ml anaphylatoxin complement 5a (C5a) (R & D Systems and 2150-C5–025) for 2 hours. Then cells were washed with cold PBS, fixed with 4% paraformaldehyde for 15 min, permeabilized

(14) C3a elicits unique migratory responses in immature low-density neutrophilsOncogeneMarch 1, 2020Hsu BE, Roy J, Mouhanna J, Rayes RF, Ramsay L, Tabariès S, Annis MG, Watson IR, Spicer JD, Costantino S, et al.

(15) Macrophage centripetal migration drives spontaneous healing process after spinal cord injuryScience advancesMay 1, 2019Kobayakawa K, Ohkawa Y, Yoshizaki S, Tamaru T, Saito T, Kijima K, Yokota K, Hara M, Kubota K, Matsumoto Y, et al.

(16) The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4Scientific reportsMarch 14, 2019Funk N, Munz M, Ott T, Brockmann K, Wenninger-Weinzierl A, Kühn R, Vogt-Weisenhorn D, Giesert F, Wurst W, Gasser T, et al.

(17) Critical role of C5a in sickle cell diseaseAmerican journal of hematologyMarch 1, 2019Vercellotti GM, Dalmasso AP, Schaid TR Jr, Nguyen J, Chen C, Ericson ME, Abdulla F, Killeen T, Lindorfer MA, Taylor RP, et al.

(18) A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritisNature immunologyFebruary 1, 2019Arandjelovic S, Perry JSA, Lucas CD, Penberthy KK, Kim TH, Zhou M, Rosen DA, Chuang TY, Bettina AM, Shankman LS, et al.

(19) Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitroFrontiers in cellular neuroscienceJanuary 1, 2019Muth C, Hartmann A, Sepulveda-Falla D, Glatzel M, Krasemann S.the cells were treated for transwell assay with 20 ng/ml of recombinant mouse complement factor C5a (#2150-C5-025, R&D Systems, MN, United States) for 2 h. Additionally, N9 microglia were immune activated to perform

(20) C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in miceEuropean journal of immunologyApril 1, 2018Syed SN, Rau E, Ziegelmann M, Sogkas G, Brüne B, Schmidt RE.

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Complement Component C5a Protein

Complement Component C5a Protein

Complement Component C5a Protein

Complement Component C5a Protein

Complement Component C5a Protein

Recombinant Mouse Complement Component C5a Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse Complement Component C5a Protein from R&D Systems, a Bio-Techne Brand

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