DNA fragment purification kits and reagents are available for necessary procedures in molecular biology. An example is in purifying PCR products from reactions and gels, or for cleaning up fragments from ligation reactions. Ready-to-use DNA fragment isolation kits can thus prove essential in next gen sequencing workflows. Such kits, which can utilize spin column or magnetic formats, can produce high yields of the desired DNA. Accommodated fragment sizes may vary with each kit and should be taken into consideration before making a decision.