Size exclusion spin columns are an invaluable tool for purifying and separating nucleic acids or proteins. They can be used to prep DNA, RNA or protein samples for many protocols, particularly those involving PCR, sequencing, or protein recovery. Spin columns can be used for basic prep steps like desalting or buffer exchange, and can also be used to concentrate proteins or clean up a dirty sample. Specialized spin columns can also be used for labeled nucleic acids, such as those labeled with fluorescent dyes or radioisotopes. Spin columns are typically compatible with standard centrifuge tubes. Quality is a crucially important consideration in choosing a spin column, since your precious sample will pass through it, and its purity will depend on the performance and integrity of the column.