ABCB11 ELISA kits are immunoassay tools for the measurement of the protein ATP binding cassette subfamily B member 11, which is encoded by the ABCB11 gene in humans. Functionally, this protein is known to catalyze the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. The canonical protein structure is reported to have an amino acid length of 1321 residues, a mass of 146.4 kDa, and is a member of the ABCB protein family. It is known to be localized in the cell membrane and is noted to be expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ. The protein has been noted to be post-translationally N-glycosylated and ubiquitinated. The ABCB11 gene has been associated with the disease, Cholestasis. Other alias names for this target include BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP, bile salt export pump, and ABC16.
The detection range for different ABCB11 ELISA kits can vary, with some assays measuring target concentrations as low as 10 ng/L and as high as 10 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.