Anti-PRDX1 antibodies are used in the immunodetection of the protein peroxiredoxin 1. In humans, the canonical protein has a reported length of 199 amino acid residues and a mass of 22.1 kDa. Its subcellular localization is in the cytoplasm. It is notably widely expressed in many tissue types. A member of the Peroxiredoxin protein family, PRDX1 is reported to be a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Post-translational modifications have been described, including phosphorylation.
The PRDX1 marker can be used to identify Common Lymphoid Progenitors (CLP).* Synonyms for this target antigen include NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, and MSP23. PRDX1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 120 citations in the literature describe the use of PRDX1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4