Anti-dynein 2 intermediate chain 1 antibodies are used for the immunodetection of the protein encoded by the DYNC2I1 gene. In humans, the canonical protein has a reported length of 1066 amino acid residues and a mass of 122.6 kDa. Its subcellular localization is in the cell projections and cytoplasm. It is reported to be expressed in chondrocytes. A member of the Dynein light intermediate chain protein family, it is known to act as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. The gene encoding this protein is implicated in Short-rib thoracic dysplasia 8 with or without polydactyly. Other names for this target antigen include DIC6, FAP163, SRPS6, SRTD8, WDR60, cytoplasmic dynein 2 intermediate chain 1, WD repeat domain 60, and CFAP163. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.