Anti-SMCR8-C9orf72 complex subunit antibodies are used for the immunodetection of the protein encoded by the SMCR8 gene. In humans, the canonical protein has a reported length of 937 amino acid residues and a mass of 105 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in all tissues tested. A member of the SMCR8 protein family, it is a known component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include Smith-Magenis syndrome chromosome region, candidate 8, smith-Magenis syndrome chromosomal region candidate gene 8 protein, and guanine nucleotide exchange protein SMCR8. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chicken species.