Anti-SRY-box transcription factor 7 antibodies are used for the immunodetection of the protein encoded by the SOX7 gene. In humans, the canonical protein has a reported length of 388 amino acid residues and a mass of 42.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is found to be widely expressed in adult and fetal tissues. It is known to bind to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). Other names for this target antigen include SRY (sex determining region Y)-box 7, SRY-box 7, and transcription factor SOX-7. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.