InstrumentationFLIPRTETRA®, FlexStation® 3
ReadoutscAMP, calcium, membrane potential, binding
GPCR ScreeningCell-based screens performed with calcium-sensitive or membrane-potential-sensitive dyes. Gs- and Gi-coupled GPCRs are assayed via cAMP determinations using either a cell-based real time cAMP assay or other validated cAMP assay platform. EC50 / IC50 determinations on confirmed actives are offered as a follow-up option. All screens include positive controls and a comprehensive report.
GPCR ProfilingCompound profiling against multiple receptors to determine specificity or off-target activity.
Mode of Action StudiesFull characterization of orthostatic and allosteric ligands.
GPCR Functional SelectivityMeasurement of GPCR functional selectivity and differentiation from assay format artefacts.
ChanTest Compound LibraryOur diverse, custom-made compound library consists of 12,600 compounds (40 384-well plates). Library screen turnaround is one business week and includes EC50 / IC50 follow-up of confirmed actives identified in the screen.
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